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Review
. 2019 Nov 22;8(12):2059.
doi: 10.3390/jcm8122059.

Cross-Talk between Lipoproteins and Inflammation: The Role of Microvesicles

Gemma Chiva-Blanch  1 , Lina Badimon  1   2
Affiliations
Review

Cross-Talk between Lipoproteins and Inflammation: The Role of Microvesicles

Gemma Chiva-Blanch et al. J Clin Med. .

Abstract

Atherothrombosis is the principal underlying cause of cardiovascular disease (CVD). Microvesicles (MV) are small blebs originated by an outward budding at the cell plasma membranes, which are released in normal conditions. However, MV release is increased in pathophysiologic conditions such as CVD. Low density lipoprotein (LDL) and MV contribute to atherothrombosis onset and progression by promoting inflammation and leukocyte recruitment to injured endothelium, as well as by increasing thrombosis and plaque vulnerability. Moreover, (oxidized)LDL induces MV release and vice-versa, perpetuating endothelium injury leading to CVD progression. Therefore, MV and lipoproteins exhibit common features, which should be considered in the interpretation of their respective roles in the pathophysiology of CVD. Understanding the pathways implicated in this process will aid in developing novel therapeutic approaches against atherothrombosis.

Keywords: LDL cholesterol; atherothrombosis; cardiovascular disease; endothelial cells; inflammation; leukocytes; lipoproteins; microparticles; microvesicles; platelets.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Particle size of lipoproteins and microvesicles. HDL, high density lipoprotein; LDL, low density lipoprotein; IDL, intermediate density lipoprotein; VLDL, very low density lipoprotein; and MV, microvesicles.
Figure 2
Figure 2
Lipid and microvesicle crosstalk contributing to atherosclerosis progression.
See this image and copyright information in PMC

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