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. 2019 Nov;24(46):1900656.
doi: 10.2807/1560-7917.ES.2019.24.46.1900656.

Decreasing and stabilising trends of antimicrobial consumption and resistance in Escherichia coli and Klebsiella pneumoniae in segmented regression analysis, European Union/European Economic Area, 2001 to 2018

Germán Peñalva  1 , Liselotte Diaz Högberg  2 , Klaus Weist  2 , Vera Vlahović-Palčevski  3 , Ole Heuer  2 , Dominique L Monnet  2 ; ESAC-Net study group  4 ; EARS-Net study group  5
Collaborators, Affiliations

Decreasing and stabilising trends of antimicrobial consumption and resistance in Escherichia coli and Klebsiella pneumoniae in segmented regression analysis, European Union/European Economic Area, 2001 to 2018

Germán Peñalva et al. Euro Surveill. 2019 Nov.

Abstract

Investments to reduce the spread of antimicrobial resistance (AMR) in the European Union have been made, including efforts to strengthen prudent antimicrobial use. Using segmented regression, we report decreasing and stabilising trends in data reported to the European Surveillance of Antimicrobial Consumption Network and stabilising trends in data reported to the European Antimicrobial Resistance Surveillance Network. Our results could be an early indication of the effect of prioritising AMR on the public health agenda.

Keywords: Antimicrobial consumption; Escherichia coli; Klebsiella pneumoniae; antimicrobial resistance; bacterial infections; carbapenem; defined daily dose; fluoroquinolone; third-generation cephalosporin.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
Consumption of third-generation cephalosporins by sector and third-generation cephalosporin resistance by microorganism, including detected trend segments, EU/EEA population-weighted means, 2001–2018
Figure 2
Figure 2
Consumption of fluoroquinolones by sector, and fluoroquinolone resistance by microorganism, including detected trend segments, EU/EEA population-weighted means, 2001–2018
Figure 3
Figure 3
Consumption of carbapenems in the hospital sector and carbapenems resistance in Klebsiella pneumoniae, including detected trend segments, EU/EEA population-weighted means, 2001–2018
See this image and copyright information in PMC

References

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