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Comment
. 2019 Nov 15;79(22):5702-5703.
doi: 10.1158/0008-5472.CAN-19-2995.

Personalized Cancer Therapy: YES1 Is the New Kid on the Block

Kunal Rai  1
Affiliations
Comment

Personalized Cancer Therapy: YES1 Is the New Kid on the Block

Kunal Rai. Cancer Res. .

Abstract

The key bottleneck for the continued success of precision medicine in cancer lies in identifying more targetable genes and associated efficacious clinically usable inhibitors. In this issue of Cancer Research, Hamanaka and colleagues identify YES1 kinase as a targetable cancer target and generate an effective chemical inhibitor for YES1 and demonstrate its efficacy in YES1-amplified tumors.See related article by Hamanaka et al., p. 5734.

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Comment in

  • YES1 Is a Targetable Oncogene in Cancers Harboring YES1 Gene Amplification.
    Hamanaka N, Nakanishi Y, Mizuno T, Horiguchi-Takei K, Akiyama N, Tanimura H, Hasegawa M, Satoh Y, Tachibana Y, Fujii T, Sakata K, Ogasawara K, Ebiike H, Koyano H, Sato H, Ishii N, Mio T. Hamanaka N, et al. Cancer Res. 2019 Nov 15;79(22):5734-5745. doi: 10.1158/0008-5472.CAN-18-3376. Epub 2019 Aug 7. Cancer Res. 2019. PMID: 31391186

Comment on

  • YES1 Is a Targetable Oncogene in Cancers Harboring YES1 Gene Amplification.
    Hamanaka N, Nakanishi Y, Mizuno T, Horiguchi-Takei K, Akiyama N, Tanimura H, Hasegawa M, Satoh Y, Tachibana Y, Fujii T, Sakata K, Ogasawara K, Ebiike H, Koyano H, Sato H, Ishii N, Mio T. Hamanaka N, et al. Cancer Res. 2019 Nov 15;79(22):5734-5745. doi: 10.1158/0008-5472.CAN-18-3376. Epub 2019 Aug 7. Cancer Res. 2019. PMID: 31391186

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