Lactate rewires synovial T cells in RA

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Comment

Joanna Clarke. Nat Rev Rheumatol. 2020 Jan.

. 2020 Jan;16(1):4.

doi: 10.1038/s41584-019-0344-1.

No abstract available

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Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4⁺ T Cell Metabolic Rewiring.
Pucino V, Certo M, Bulusu V, Cucchi D, Goldmann K, Pontarini E, Haas R, Smith J, Headland SE, Blighe K, Ruscica M, Humby F, Lewis MJ, Kamphorst JJ, Bombardieri M, Pitzalis C, Mauro C. Pucino V, et al. Cell Metab. 2019 Dec 3;30(6):1055-1074.e8. doi: 10.1016/j.cmet.2019.10.004. Epub 2019 Nov 7. Cell Metab. 2019. PMID: 31708446 Free PMC article.

1. Pucino, V. et al. Lactate buildup at the site of chronic inflammation promotes disease by inducing CD4⁺ T cell metabolic rewiring. Cell Metabolism https://doi.org/10.1016/j.cmet.2019.10.004 (2019) - DOI - PubMed