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Review
. 2019 Oct 21:2019:5920620.
doi: 10.1155/2019/5920620. eCollection 2019.

Effects of Anesthetics on Barrier Tissue Function

Fujing Wang  1 , Yanhui Li  1 , Changlei Cui  1 , Zhaoping Xue  2 , Haichun Ma  1
Affiliations
Review

Effects of Anesthetics on Barrier Tissue Function

Fujing Wang et al. J Immunol Res. .

Abstract

Anesthetics have long been proven to have additional effects other than anesthesia on different organs and tissues of the human body. Barrier tissues play critical roles in human health and diseases, yet the impacts of anesthetics on barrier tissues are still not clear. This review article is aimed at summarizing different effects of anesthetics on the skin, the respiratory, and intestinal membranes from two aspects: inflammation/immunity and ischemia-reperfusion. Among volatile, intravenous, and local anesthetics, volatile anesthetics are less influential on barrier ischemia-perfusion function. Although direct comparisons between volatile and the other two types of anesthetics are still lacking, volatile anesthetics appear to have stronger anti-inflammatory effects on different barrier tissues through various mechanisms. These results suggested that when treating patients with barrier tissue complications, volatile anesthetics can provide better therapeutic outcomes.

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Conflict of interest statement

The authors declare that there is no conflict of interest regarding the publication of this paper.

Figures

Figure 1
Figure 1
Major division and representative drug—function diagram. The main methods of anesthesia, the major classification of each, and the representative agents mentioned in the references were listed. The functions on barrier tissue of agents were classified, and the numbers refer to the references.
See this image and copyright information in PMC

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