doi: 10.1002/ajmg.1320300151.
A non-syndromal form of X-linked mental retardation (XLMR) is linked to DXS14
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- PMID: 3177466
- DOI: 10.1002/ajmg.1320300151
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A non-syndromal form of X-linked mental retardation (XLMR) is linked to DXS14
Am J Med Genet.
1988 May-Jun.
Abstract
An analysis of the linkage of a non-syndromal form of X-linked mental retardation (MRX1) with a number of markers on the X chromosome was performed in a large pedigree. The affected males had moderate mental retardation; in all other clinical respects and cytogenetically they were normal. No recombinants were observed between the MRX1 gene and the marker DXS14 (p58.1) located at Xp11-cen (Z (max.) = 2.12 at theta = 0.00). Recombination was observed between the MRX1 gene and the markers DXS7 and DXYS1 which flank DXS14. This form of XLMR maps to the centromeric portion of the X-chromosome.
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