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. 2020 Mar;379(3):511-520.
doi: 10.1007/s00441-019-03108-5. Epub 2019 Nov 27.

Lymphatic vessels in human adipose tissue

Patricia de Albuquerque Garcia Redondo  1   2 , Fernanda Gubert  3   4 , Camila Zaverucha-do-Valle  4   5 , Tatiana Pereira Pena Dutra  6 , Jackline de Paula Ayres-Silva  7 , Natasha Fernandes  8 , Antonio Augusto Peixoto de Souza  9 , Marilena Loizidou  10 , Christina Maeda Takiya  8 , Maria Isabel Doria Rossi  11   12 , Radovan Borojevic  13
Affiliations

Lymphatic vessels in human adipose tissue

Patricia de Albuquerque Garcia Redondo et al. Cell Tissue Res. 2020 Mar.

Abstract

Despite being considered present in most vascularised tissues, lymphatic vessels have not been properly shown in human adipose tissue (AT). Our goal in this study is to investigate an unanswered question in AT biology, regarding lymphatic network presence in tissue parenchyma. Using human subcutaneous (S-) and visceral (V-) AT samples with whole mount staining for lymphatic specific markers and three-dimensional imaging, we showed lymphatic capillaries and larger lymphatic vessels in the human VAT. Conversely, in the human SAT, microcirculatory lymphatic vascular structures were rarely detected and no initial lymphatics were found.

Keywords: Adipose; Lymphatics; Subcutaneous; Vessels; Visceral.

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