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Review
. 2016 Dec;29(4):353-362.
doi: 10.1055/s-0036-1584086.

Prevention of Colorectal Neoplasia

Scott C Dolejs  1 , Benjamin Gayed  1 , Alyssa Fajardo  1
Affiliations
Review

Prevention of Colorectal Neoplasia

Scott C Dolejs et al. Clin Colon Rectal Surg. 2016 Dec.

Abstract

Colorectal cancer (CRC) is one of the leading causes of cancer-related morbidity and mortality worldwide. There are well-established screening protocols involving fecal testing, radiographic, and endoscopic evaluations that have led to decreased incidence and mortality of CRC in the United States. In addition to screening for CRC, there is interest in preventing colorectal neoplasia by targeting the signaling pathways that have been identified in the pathway of dysplasia progressing to carcinoma. This review will detail the efficacy of multiple potential preventative strategies including lifestyle changes (physical activity, alcohol use, smoking cessation, and obesity); dietary factors (dietary patterns, calcium, vitamin D, fiber, folate, and antioxidants and micronutrients); and chemopreventive agents (nonsteroidal anti-inflammatory drugs, statins, metformin, bisphosphonates, and postmenopausal hormonal therapy).

Keywords: adenoma; chemoprevention; colorectal cancer; primary prevention.

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References

    1. Kohler B A, Sherman R L, Howlader N. et al.Annual report to the Nation on the Status of Cancer, 1975-2011, featuring incidence of breast cancer subtypes by race/ethnicity, poverty, and state. J Natl Cancer Inst. 2015;107(6):djv048. - PMC - PubMed
    1. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin. 2010;60(5):277–300. - PubMed
    1. Winawer S J, Zauber A G, Ho M N. et al.Prevention of colorectal cancer by colonoscopic polypectomy. N Engl J Med. 1993;329(27):1977–1981. - PubMed
    1. Mandel J S, Bond J H, Church T R. et al.Reducing mortality from colorectal cancer by screening for fecal occult blood. Minnesota Colon Cancer Control Study. N Engl J Med. 1993;328(19):1365–1371. - PubMed
    1. Kronborg O, Fenger C, Olsen J, Jørgensen O D, Søndergaard O. Randomised study of screening for colorectal cancer with faecal-occult-blood test. Lancet. 1996;348(9040):1467–1471. - PubMed