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Review
. 2019 Oct 22;10(26):6693-6702.
doi: 10.7150/jca.30877. eCollection 2019.

Recent Progress in Characterizing Long Noncoding RNAs in Cancer Drug Resistance

Wenyuan Zhao  1 , Bin Shan  2 , Dan He  3 , Yuanda Cheng  4 , Bin Li  1 , Chunfang Zhang  4 , Chaojun Duan  1   5   6
Affiliations
Review

Recent Progress in Characterizing Long Noncoding RNAs in Cancer Drug Resistance

Wenyuan Zhao et al. J Cancer. .

Abstract

Drug resistance is an important cause of failure in cancer chemotherapies. A large number of long noncoding RNAs (lncRNAs) have been found to be related to drug resistance in cancers. Therefore, lncRNAs provide potential targets for cancer therapies. The lncRNAs involved in cancer drug resistance are attracting interest from an increasing number of researchers. This review summarizes the latest research on the mechanisms and functions of lncRNAs in cancer drug resistance and envisages their future developments and therapeutic applications. This research suggests that lncRNAs regulate drug resistance through multiple mechanisms. LncRNAs do not affect drug resistance directly; usually, they do so by regulating the expression of some intermediate regulatory factors. In addition, lncRNAs exhibit a diversity of functions in cancer drug resistance. The overexpression of most lncRNAs promotes drug resistance, while a few lncRNAs have inhibitory effects.

Keywords: cancer; chemotherapy; drug resistance; exosome; lncRNA.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
Mechanisms of glycolysis regulated by four lncRNAs. Symbols: brown ellipses - enzymes; brown Y shape - receptor (PPARγ).
Figure 2
Figure 2
Mechanisms of drug resistance regulated by exosomes in microenvironments. Symbols: red cells - red blood cells; blue cells - cancer cells; yellow cells -fibroblast; brown dots - exosomes; green curve - lncRNA UCA1; black arrows - for A1~A4; red arrows - for B1~B3.
Figure 3
Figure 3
Mechanisms of drug resistance regulated by astragali radix and lncRNA ROR. Symbols: blue cells—breast cancer cells; red circle—nuclear membranes; brown dots—enzymes; yellow net—endoplasmic reticulum; pink ellipses—mitochondria.
See this image and copyright information in PMC

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