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. 1988 May-Jun;9(3):117-26.
doi: 10.1016/s0196-0709(88)80017-6.

Mechanism of bone destruction due to middle ear cholesteatoma as revealed by laser-Raman spectrometry

K Ohsaki  1 , S Yamashita, A Fujita, Y Masuda, S Ueda, T Sugiura, K Tamura, A Shibata
Affiliations

Mechanism of bone destruction due to middle ear cholesteatoma as revealed by laser-Raman spectrometry

K Ohsaki et al. Am J Otolaryngol. 1988 May-Jun.

Abstract

In an investigation of the mechanism of bone destruction caused by chronic otitis media complicated with cholesteatoma, both the processes of demineralization and remineralization were studied in an animal model and clinically at the molecular level, using a laser-Raman spectrometer. From this investigation, it is proposed that the mechanism of bone destruction associated with cholesteatoma is a form of demineralization.

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