Excessive breakthrough bleeding in haemophilia B patients on factor IX-albumin fusion protein prophylactic therapy: A single centre case series

Brendan Kleiboer^{1

2}, Brenda Nielsen², Alica D Ma^{2

3}, Yasmina Abajas^{1

2}, Dougald M Monroe³, Nigel S Key^{2

3}

Affiliations

¹ Department of Pediatrics, University of North Carolina, Chapel Hill, NC, USA.
² Hemophilia and Thrombosis Center, University of North Carolina, Chapel Hill, NC, USA.
³ Department of Medicine, University of North Carolina, Chapel Hill, NC, USA.

Case Reports

Brendan Kleiboer et al. Haemophilia. 2020 Jan.

. 2020 Jan;26(1):e23-e25.

doi: 10.1111/hae.13896. Epub 2019 Nov 27.

Brendan Kleiboer^{1

2}, Brenda Nielsen², Alica D Ma^{2

3}, Yasmina Abajas^{1

2}, Dougald M Monroe³, Nigel S Key^{2

3}

¹ Department of Pediatrics, University of North Carolina, Chapel Hill, NC, USA.
² Hemophilia and Thrombosis Center, University of North Carolina, Chapel Hill, NC, USA.
³ Department of Medicine, University of North Carolina, Chapel Hill, NC, USA.

No abstract available

References

1. Santagostino E, Martinowitz U, Lissitchkov T, et al. Long-acting recombinant coagulation factor IX albumin fusion protein (rFIX-FP) in hemophilia B: results of a phase 3 trial. Blood. 2016; 127(14):1761–9. - PMC - PubMed
1. Korth-Bradley JM, Rendo P, Smith L, et al. Altisent C Pharmacokinetics, efficacy, and safety of Nonacog Alfa in previously treated patients with moderately severe to severe hemophilia B. Clin Ther. 2016; 38(4):936–944. - PubMed
1. Björkman S Population pharmacokinetics of recombinant factor IX: implications for dose tailoring. Haemophilia. 2013; 19(5):753–757. - PubMed
1. Diao L, Li S, Ludden T, Gobburu J, Nestorov I, Jiang H. Population pharmacokinetic modelling of recombinant factor IX Fc fusion protein (rFIXFc) in patients with haemophilia B. Clin Pharmacokinet. 2014; 53(5): 467–477. - PMC - PubMed
1. Santagostino E, Negrier C, Klamroth R, et al. Safety and pharmacokinetics of a novel recombinant fusion protein linking coagulation factor IX with albumin (rFIX-FP) in hemophilia B patients. Blood. 2012; 120(12): 2405–2411. - PMC - PubMed