Edaravone for amyotrophic lateral sclerosis: More evidence for long-term benefit
- PMID: 31778230
- DOI: 10.1002/mus.26770
Edaravone for amyotrophic lateral sclerosis: More evidence for long-term benefit
Comment on
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Long-term edaravone efficacy in amyotrophic lateral sclerosis: Post-hoc analyses of Study 19 (MCI186-19).Muscle Nerve. 2020 Feb;61(2):218-221. doi: 10.1002/mus.26740. Epub 2019 Nov 11. Muscle Nerve. 2020. PMID: 31621933 Free PMC article. Clinical Trial.
References
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- Writing Group. Edaravone (MCI-186) ALS 19 Study Group. Safety and efficacy of edaravone in well-defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2017;16:505-512.
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- Ahmadinejad F, Geir Møller S, Hashemzadeh-Chaleshtori M, Bidkhori G, Jami MS. Molecular mechanisms behind free radical scavengers function against oxidative stress. Antioxidants (Basel). 2017;6.
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- Ito H, Wate R, Zhang J, et al. Treatment with edaravone, initiated at symptom onset, slows motor decline and decreases SOD1 deposition in ALS mice. Exp Neurol. 2008;213:448-455.
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- Writing Group on Behalf of the Edaravone ALS 19 Study Group. Open-label 24-week extension study of edaravone (MCI-186) in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2017;18(Suppl 1):55-63.
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