Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2019 Nov 28;134(22):1881-1882.
doi: 10.1182/blood.2019002805.

Cardiovascular adverse events of ibrutinib

Inhye E Ahn
Comment

Cardiovascular adverse events of ibrutinib

Inhye E Ahn. Blood. .

Abstract

In this issue of Blood, Dickerson et al report on the increased incidence and worsening severity of hypertension and its association with cardiovascular outcomes in 562 patients treated with ibrutinib for B-cell malignancies.

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest disclosure: The author declares no competing financial interests.

Comment on

References

    1. Dickerson T, Wiczer T, Waller A, et al. . Hypertension and incident cardiovascular events following ibrutinib initiation. Blood. 2019;134(22):1919-1928. - PMC - PubMed
    1. Dubovsky JA, Beckwith KA, Natarajan G, et al. . Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes. Blood. 2013;122(15):2539-2549. - PMC - PubMed
    1. Chen J, Kinoshita T, Sukbuntherng J, Chang BY, Elias L. Ibrutinib inhibits ERBB receptor tyrosine kinases and HER2-amplified breast cancer cell growth. Mol Cancer Ther. 2016;15(12):2835-2844. - PubMed
    1. Leong DP, Caron F, Hillis C, et al. . The risk of atrial fibrillation with ibrutinib use: a systematic review and meta-analysis. Blood. 2016;128(1):138-140. - PubMed
    1. Woyach JA, Ruppert AS, Heerema NA, et al. . Ibrutinib regimens versus chemoimmunotherapy in older patients with untreated CLL. N Engl J Med. 2018;379(26):2517-2528. - PMC - PubMed