Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2019 Nov 12:10:2611.
doi: 10.3389/fimmu.2019.02611. eCollection 2019.

Epidemiology of Antibody-Positive Autoimmune Encephalitis in Southwest China: A Multicenter Study

Yixue Gu  1 , Min Zhong  2 , Liang He  3 , Wei Li  4 , Yuanyuan Huang  5 , Jing Liu  6 , Yangmei Chen  3 , Zheng Xiao  1
Affiliations
Multicenter Study

Epidemiology of Antibody-Positive Autoimmune Encephalitis in Southwest China: A Multicenter Study

Yixue Gu et al. Front Immunol. .

Abstract

In recent years, as an increasing number of neuronal autoantibodies have been detected and used for clinical diagnosis, clinicians have become more aware of autoimmune encephalitis, causing its reported incidence to trend upward over several years. To date, however, there has been no large-scale epidemiological survey of autoimmune encephalitis in adults and children, and its epidemiological characteristics remain unclear. Six main types of antibodies are detected and used to diagnose autoimmune encephalitis in Chongqing, Southwestern China: anti-NMDA receptor antibody, anti-GABAB receptor antibody, anti-LGI1 antibody, anti-CASPR2 antibody, anti-AMPA1 receptor antibody, and anti-AMPA2 receptor antibody. From January 2012 to February 2018, 189 patients at six general hospitals in Chongqing were diagnosed with autoimmune encephalitis and were positive for neuronal autoantibodies. In this report, the epidemic situation and the antibody distribution among these patients are analyzed and described in detail. The differences in disease severity among different ages and between the sexes are evaluated, and the correlation between antibody titer and disease severity is also assessed.

Keywords: age; autoimmune encephalitis; epidemiology; neuronal autoantibodies; sex.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Trends in the numbers of annual diagnosed cases of AE and non-NMDAR encephalitis.
See this image and copyright information in PMC

Comment in

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Venkatesan A, Tunkel AR, Bloch KC, Lauring AS, Sejvar J, Bitnun A, et al. . Case definitions, diagnostic algorithms, and priorities in encephalitis: consensus statement of the international encephalitis consortium. Clin Infect Dis. (2013) 57:1114–28. 10.1093/cid/cit458 - DOI - PMC - PubMed
    1. Granerod J, Ambrose HE, Davies NW, Clewley JP, Walsh AL, Morgan D, et al. . Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study. Lancet Infect Dis. (2010) 10:835–44. 10.1016/S1473-3099(10)70222-X - DOI - PubMed
    1. Mailles A, Stahl JP. Steering Committee and Investigators Group. Infectious encephalitis in france in 2007: a national prospective study. Clin Infect Dis. (2009) 49:1838–47. 10.1086/648419 - DOI - PubMed
    1. Thakur KT, Motta M, Asemota AO, Kirsch HL, Benavides DR, Schneider EB, et al. . Predictors of outcome in acute encephalitis. Neurology. (2013) 81:793–800. 10.1212/WNL.0b013e3182a2cc6d - DOI - PMC - PubMed
    1. Graus F, Titulaer MJ, Balu R, Benseler S, Bien CG, Cellucci T, et al. . A clinical approach to diagnosis of autoimmune encephalitis. Lancet Neurol. (2016) 15:391–404. 10.1016/S1474-4422(15)00401-9 - DOI - PMC - PubMed

Publication types

Supplementary concepts