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. 2019 Oct 31:2019:6956034.
doi: 10.1155/2019/6956034. eCollection 2019.

Assessment of the Effectiveness of Vitamin Supplement in Treating Eczema: A Systematic Review and Meta-Analysis

Ziyu Zhu  1   2 , Ziyi Yang  1   2 , Chunyi Wang  1   3 , Handeng Liu  1
Affiliations

Assessment of the Effectiveness of Vitamin Supplement in Treating Eczema: A Systematic Review and Meta-Analysis

Ziyu Zhu et al. Evid Based Complement Alternat Med. .

Abstract

Background: The morbidity of eczema has increased in the recent years, and the methods to prevent or ameliorate its effects are becoming more important. To this end, this research was conducted to determine the effectiveness of vitamin supplements in eczema therapy.

Method: Embase, PubMed, and Cochrane Central Register of Clinical Trials were searched. Only randomized controlled trials were included, and we included all quantified eligible data where the SCORing Atopic Dermatitis (SCORAD) Index or Eczema Area and Severity Index (EASI) scores were applied to assess the severity of eczema.

Results: Ten studies fulfilled the inclusion criteria, and eight of them were included for quantitative analysis (total: 456 patients). Compared to the controls, the SCORAD index or EASI decreased in the vitamin supplement group (mean difference -5.96, 95% CI: -7.69 to -4.23 for vitamin D3; mean difference -5.72, 95% CI: -11.41 to -0.03 for vitamin E; and mean difference -3.19, 95% CI: -4.27 to -2.10 for vitamin B12).

Conclusion: This study suggests that vitamin supplements could be important therapeutics to help manage eczema patients.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Flow diagram of the study screening process.
Figure 2
Figure 2
Risk of bias graph of all included studies.
Figure 3
Figure 3
Risk of bias summary for each included study.
Figure 4
Figure 4
Summary of findings.
Figure 5
Figure 5
Sensitivity analysis for included studies on vitamin D3 supplementation.
Figure 6
Figure 6
Forest plot of the meta-analysis of vitamin D3 and atopic dermatitis.
Figure 7
Figure 7
Forest plot of the meta-analysis of vitamin B12 and atopic dermatitis.
Figure 8
Figure 8
Forest plot of the meta-analysis of vitamin E and atopic dermatitis.
See this image and copyright information in PMC

References

    1. Kirk M., Deckers I. A. G., McLean S., et al. Investigating international time trends in the incidence and prevalence of atopic eczema 1990–2010: a systematic review of epidemiological studies. PLoS One. 2012;7(7) doi: 10.1371/journal.pone.0039803.e39803 - DOI - PMC - PubMed
    1. Kechichian E., Ezzedine K. Vitamin D and the skin: an update for dermatologists. American Journal of Clinical Dermatology. 2018;19(2):223–235. doi: 10.1007/s40257-017-0323-8. - DOI - PubMed
    1. Hollis B. W. Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D. The Journal of Nutrition. 2005;135(2):317–322. doi: 10.1093/jn/135.2.317. - DOI - PubMed
    1. Addor F. A. S. Antioxidants in dermatology. Anais Brasileiros de Dermatologia. 2017;92(3):356–362. doi: 10.1590/abd1806-4841.20175697. - DOI - PMC - PubMed
    1. Brescoll J., Daveluy S. A review of vitamin B12 in dermatology. American Journal of Clinical Dermatology. 2015;16(1):27–33. doi: 10.1007/s40257-014-0107-3. - DOI - PubMed

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