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Case Reports
. 2019 Nov 6:2019:3154856.
doi: 10.1155/2019/3154856. eCollection 2019.

Oral Lichenoid Reaction: An Uncommon Side Effect of Rituximab

Amerigo Giudice  1 , Francesco Liborio  1 , Fiorella Averta  1 , Selene Barone  1 , Leonzio Fortunato  1
Affiliations
Case Reports

Oral Lichenoid Reaction: An Uncommon Side Effect of Rituximab

Amerigo Giudice et al. Case Rep Dent. .

Abstract

Oral lichenoid reactions (OLR) can be caused by systemic drug exposure. To the best of our knowledge, this is the second report describing a case of OLR induced by rituximab administration in a patient with a diagnosis of non-Hodgkin B-cell lymphoma. After 5 doses of rituximab, a typical pattern of OLP was identified with bilateral and symmetrical lesions on the buccal mucosa and on the right lingual margin. This temporal relationship suggested a probable association between oral lesions and drug therapy. The clinical diagnosis of a rituximab-induced OLR was confirmed by an incisional biopsy reporting a histopathological result of lichenoid mucositis consistent with oral lichen planus. Because of the increasing use of rituximab, it is necessary to know and recognize this uncommon side effect.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
After rituximab therapy, ulcers surrounded by white reticulation and erythema on the left buccal mucosa (a), right buccal mucosa (b), can be observed.
Figure 2
Figure 2
Extensive ulcer localized on the right margin of the tongue.
See this image and copyright information in PMC

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