Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2019 Nov 12:2019:3503651.
doi: 10.1155/2019/3503651. eCollection 2019.

Hypercalcemic Crisis in a Patient with Post-Surgical Hypoparathyroidism

Affiliations
Case Reports

Hypercalcemic Crisis in a Patient with Post-Surgical Hypoparathyroidism

Wannita Tingsarat et al. Case Rep Endocrinol. .

Abstract

Calcium alkali syndrome (CAS), a relatively unusual etiology of hypercalcemia, is characterized by a classical triad of hypercalcemia, azotemia, and metabolic alkalosis. This condition has been described in patients who have taken an excess dose of calcium with an alkali or with a volume-depletion status. To diagnose CAS it requires a high index of suspicion and a detailed history of medication/supplement intake specifically for calcium-containing drugs and a history of all possible ingested alkali. We reported a case of post-surgical hypoparathyroidism whom later on was presented with hypercalcemic crisis due to CAS. The proposed mechanism of CAS and management are also included.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflicts of interest.

References

    1. Edafe O., Antakia R., Laskar N., Balasubramanian S. P. Systematic review and meta-analysis of predictors of post-thyroidectomy hypocalcaemia. British Journal of Surgery. 2014;101(4):307–320. doi: 10.1002/bjs.9384. - DOI - PubMed
    1. Orloff L. A., Wiseman S. M., Bernet V. J., et al. American thyroid association statement on postoperative hypoparathyroidism: diagnosis, prevention, and management in adults. Thyroid. 2018;28(7):830–841. doi: 10.1089/thy.2017.0309. - DOI - PubMed
    1. Picolos M. K., Lavis V. R., Orlander P. R. Milk-alkali syndrome is a major cause of hypercalcaemia among non-end-stage renal disease (non-ESRD) inpatient. Clinical Endocrinology. 2005;63(5):566–576. doi: 10.1111/j.1365-2265.2005.02383.x. - DOI - PubMed
    1. Patel A. M., Adeseun G. A., Goldfarb S. Calcium-alkali syndrome in the modern era. Nutrients. 2013;5(12):4880–4893. doi: 10.3390/nu5124880. - DOI - PMC - PubMed
    1. Fung T. Y., Havekes B., Cornelis T. Milk-alkali syndrome sine alkalosis; an elusive cause of intermittent hypercalcemia. International Urology and Nephrology. 2013;45(6):1791–1793. doi: 10.1007/s11255-012-0281-2. - DOI - PubMed

Publication types

LinkOut - more resources