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Review
. 2019 Nov 8:9:1153.
doi: 10.3389/fonc.2019.01153. eCollection 2019.

Modulation of Multiple Signaling Pathways of the Plant-Derived Natural Products in Cancer

Li-Rui Sun  1 , Wei Zhou  1 , Hong-Mei Zhang  1 , Qiu-Shi Guo  1 , Wei Yang  2 , Bing-Jin Li  2 , Zhi-Hui Sun  1 , Shuo-Hui Gao  3 , Ran-Ji Cui  2
Affiliations
Review

Modulation of Multiple Signaling Pathways of the Plant-Derived Natural Products in Cancer

Li-Rui Sun et al. Front Oncol. .

Abstract

Natural compounds are highly effective anticancer chemotherapeutic agents, and the targets of plant-derived anticancer agents have been widely reported. In this review, we focus on the main signaling pathways of apoptosis, proliferation, invasion, and metastasis that are regulated by polyphenols, alkaloids, saponins, and polysaccharides. Alkaloids primarily affect apoptosis-related pathways, while polysaccharides primarily target pathways related to proliferation, invasion, and metastasis. Other compounds, such as flavonoids and saponins, affect all of these aspects. The association between compound structures and signaling pathways may play a critical role in drug discovery.

Keywords: alkaloid; cancer; natural active compounds; polyphenol; polysaccharide; saponin; signaling pathway.

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Figures

Figure 1
Figure 1
Chemical structures of some flavonoids.
Figure 2
Figure 2
Chemical structures of some stilbenes.
Figure 3
Figure 3
Chemical structures of some lignans.
Figure 4
Figure 4
Chemical structures of some xanthones.
Figure 5
Figure 5
Chemical structures of some alkaloids.
Figure 6
Figure 6
Chemical structures of some saponins.
Figure 7
Figure 7
Chemical structures of ginsenosides.
Figure 8
Figure 8
Signaling pathways of the natural products.
See this image and copyright information in PMC

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