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. 2020 Aug 1;58(6):848-851.
doi: 10.1093/mmy/myz121.

Susceptibility of uncommon Candida species to systemic antifungals by the EUCAST methodology

Judith Díaz-García  1   2 , Luis Alcalá  1   2   3 , Pablo Martín-Rabadán  1   2   3 , Aina Mesquida  1   2 , Carlos Sánchez-Carrillo  1   2   3 , Elena Reigadas  1   2   3 , Patricia Muñoz  1   2   3   4 , Pilar Escribano  1   2 , Jesús Guinea  1   2   3
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Susceptibility of uncommon Candida species to systemic antifungals by the EUCAST methodology

Judith Díaz-García et al. Med Mycol. .

Abstract

The incidence of infections by uncommon Candida species has increased in recent years, however, in vitro susceptibility data are scarce. Here we assess the susceptibility of C. krusei, C. dubliniensis, C. lusitaniae, and C. guilliermondii complex isolates (n = 120) to antifungal agents by the EUCAST methodology. C. dubliniensis proved to be the most susceptible species, similar to that of C. albicans (P < .05), whereas C. guilliermondii was the least susceptible. Two C. krusei isolates were echinocandin-resistant and harbored a point mutation (L701M) in the FKS1. Some isolates were either fluconazole-resistant (C. lusitaniae, n = 2) or fluconazole non-wild type (C. guilliermondii, n = 3).

Keywords: Candida dubliniensis; Candida guilliermondii; Candida krusei; Candida lusitaniae; EUCAST.

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