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. 2019 Nov 29;17(1):396.
doi: 10.1186/s12967-019-02149-2.

Ovarian function and reproductive outcome after ovarian tissue transplantation: a systematic review

Sepideh Sheshpari  1 , Mahnaz Shahnazi  1 , Halimeh Mobarak  2 , Shahin Ahmadian  3 , Alberto Miranda Bedate  4 , Ziba Nariman-Saleh-Fam  5 , Mohammad Nouri  6   7 , Reza Rahbarghazi  8   6 , Mahdi Mahdipour  9   10
Affiliations

Ovarian function and reproductive outcome after ovarian tissue transplantation: a systematic review

Sepideh Sheshpari et al. J Transl Med. .

Abstract

The aim of this systematic review study is to summarize the current knowledge of ovarian tissue transplantation and provide insight on ovarian function, fertility and reproductive outcome following ovarian tissue transplantation. Relevant studies were identified by searching through PubMed, Cochrane Library, Embase, ProQuest, and Scopus databases until August 2018. Ovarian function by examination of the hormonal level was evaluated, together with follicular growth, the return of menstrual cycle and assessment of reproductive consequences: pregnancy, miscarriage rates and live birth after transplantation. Studies including female patients aged between 22 and 49 years that were subjected to ovarian tissue transplantation were considered. A total of 1185 studies were identified in the primary search. Titles and abstracts were screened for assessment of the inclusion criteria. Finally, twenty-five articles met the criteria and were included in this study. In general, 70% of patients that underwent ovarian tissue transplantation had ovarian and endocrine function restoration as well as follicular growth. Pregnancy was reported with 52% of the patients. The available evidence suggests that ovarian tissue transplantation is a useful and an applied approach to restore hormonal function, endocrine balance and eventually fertility outcomes in patients that are predisposed to lose their fertility, diagnosed with premature ovarian failure (POF), as well as women undergoing cancer treatments. Identification of the techniques with the lowest invasions for follicular and oocyte development after ovarian tissue transplantation aiming to reduce probable adverse effects after treatment is indispensable.

Keywords: Cryopreservation; Fertility; Ovarian tissue; Pregnancy; Transplantation.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Schematic presentation of ovarian tissue cryopreservation and transplantation
Fig. 2
Fig. 2
PRISMA flow-chart indicated the eligible studies selection and screening process
Fig. 3
Fig. 3
Overall conception of the IVF technique after transplantation of cryopreserved ovarian tissue
See this image and copyright information in PMC

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References

    1. Anderson RA, Wallace WH, Baird DT. Ovarian cryopreservation for fertility preservation: indications and outcomes. Reproduction. 2008;136:681–689. doi: 10.1530/REP-08-0097. - DOI - PubMed
    1. Howell S, Shalet S. Gonadal damage from chemotherapy and radiotherapy. Endocrinol Metab Clin North Am. 1998;27:927–943. doi: 10.1016/S0889-8529(05)70048-7. - DOI - PubMed
    1. Lambertini M, Del Mastro L, Pescio MC, Andersen CY, Azim HA, Jr, Peccatori FA, et al. Cancer and fertility preservation: international recommendations from an expert meeting. BMC Med. 2016;14:1. doi: 10.1186/s12916-015-0545-7. - DOI - PMC - PubMed
    1. Shuster LT, Rhodes DJ, Gostout BS, Grossardt BR, Rocca WA. Premature menopause or early menopause: long-term health consequences. Maturitas. 2010;65:161–166. doi: 10.1016/j.maturitas.2009.08.003. - DOI - PMC - PubMed
    1. Okeke T, Anyaehie U, Ezenyeaku C. Premature menopause. Ann Med Health Sci Res. 2013;3:90–95. doi: 10.4103/2141-9248.109458. - DOI - PMC - PubMed

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