Chorioamnionitis: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data

doi:10.1016/j.vaccine.2019.05.030

Review

. 2019 Dec 10;37(52):7610-7622.

doi: 10.1016/j.vaccine.2019.05.030.

Chorioamnionitis: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data

Alisa Kachikis¹, Linda O Eckert¹, Christie Walker¹, Azucena Bardají², Frederick Varricchio³, Heather S Lipkind⁴, Khady Diouf⁵, Wan-Ting Huang⁶, Ronald Mataya⁷, Mustapha Bittaye⁸, Clare Cutland⁹, Nansi S Boghossian¹⁰, Tamala Mallett Moore¹¹, Rebecca McCall¹², Jay King¹¹, Shuchita Mundle¹³, Flor M Munoz¹⁴, Caroline Rouse¹⁵, Michael Gravett¹, Lakshmi Katikaneni¹⁶, Kevin Ault¹⁷, Nicola P Klein¹⁸, Drucilla J Roberts¹⁹, Sonali Kochhar²⁰, Nancy Chescheir²¹; Brighton Collaboration Chorioamnionitis Working Group

Affiliations

¹ University of Washington, Seattle, WA, USA.
² ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
³ Independent Consultant Vaccinologist, Wakefield, RI, USA.
⁴ Yale University School of Medicine, New Haven, CT, USA.
⁵ Brigham and Women's Hospital, Boston, MA, USA.
⁶ Taiwan Centers for Disease Control, Taipei, Taiwan.
⁷ Loma Linda University, Loma Linda, CA, USA; University of Malawi College of Medicine, Malawi.
⁸ Edward Francis Small Teaching Hospital, Banjul, The Gambia; Medical Research Council - The Gambia at London School of Hygiene and Tropical Medicine, Fajara, The Gambia; University of The Gambia School of Medicine & Allied Health Sciences, The Gambia.
⁹ Medical Research Council: Respiratory and Meningeal Pathogens Research Unit, Johannesburg, South Africa; Department of Science and Technology National Research Foundation, Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
¹⁰ Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
¹¹ Sanofi Pasteur, USA.
¹² University of North Carolina, Chapel Hill, NC, USA.
¹³ Government Medical College, Nagpur, India.
¹⁴ Baylor College of Medicine, Houston, TX, USA.
¹⁵ Indiana University School of Medicine, Indianapolis, IN, USA.
¹⁶ Medical University of South Carolina, Charleston, SC, USA.
¹⁷ University of Kansas Medical Center, Kansas City, KS, USA.
¹⁸ Kaiser Permanente Vaccine Study Centre, Oakland, CA, USA.
¹⁹ Massachusetts General Hospital, Boston, MA, USA.
²⁰ Global Healthcare Consulting, India; Erasmus University Medical Center, Rotterdam, the Netherlands; University of Washington, Seattle, WA, USA.
²¹ University of North Carolina, Chapel Hill, NC, USA. Electronic address: secretariat@brightoncollaboration.org.

PMID: 31783982
PMCID: PMC6891229
DOI: 10.1016/j.vaccine.2019.05.030

Review

Chorioamnionitis: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data

Alisa Kachikis et al. Vaccine. 2019.

. 2019 Dec 10;37(52):7610-7622.

doi: 10.1016/j.vaccine.2019.05.030.

Authors

Affiliations

¹ University of Washington, Seattle, WA, USA.
² ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
³ Independent Consultant Vaccinologist, Wakefield, RI, USA.
⁴ Yale University School of Medicine, New Haven, CT, USA.
⁵ Brigham and Women's Hospital, Boston, MA, USA.
⁶ Taiwan Centers for Disease Control, Taipei, Taiwan.
⁷ Loma Linda University, Loma Linda, CA, USA; University of Malawi College of Medicine, Malawi.
⁸ Edward Francis Small Teaching Hospital, Banjul, The Gambia; Medical Research Council - The Gambia at London School of Hygiene and Tropical Medicine, Fajara, The Gambia; University of The Gambia School of Medicine & Allied Health Sciences, The Gambia.
⁹ Medical Research Council: Respiratory and Meningeal Pathogens Research Unit, Johannesburg, South Africa; Department of Science and Technology National Research Foundation, Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
¹⁰ Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
¹¹ Sanofi Pasteur, USA.
¹² University of North Carolina, Chapel Hill, NC, USA.
¹³ Government Medical College, Nagpur, India.
¹⁴ Baylor College of Medicine, Houston, TX, USA.
¹⁵ Indiana University School of Medicine, Indianapolis, IN, USA.
¹⁶ Medical University of South Carolina, Charleston, SC, USA.
¹⁷ University of Kansas Medical Center, Kansas City, KS, USA.
¹⁸ Kaiser Permanente Vaccine Study Centre, Oakland, CA, USA.
¹⁹ Massachusetts General Hospital, Boston, MA, USA.
²⁰ Global Healthcare Consulting, India; Erasmus University Medical Center, Rotterdam, the Netherlands; University of Washington, Seattle, WA, USA.
²¹ University of North Carolina, Chapel Hill, NC, USA. Electronic address: secretariat@brightoncollaboration.org.

PMID: 31783982
PMCID: PMC6891229
DOI: 10.1016/j.vaccine.2019.05.030

No abstract available

Keywords: Adverse event; Amnionitis; Case definition; Chorioamnionitis; Guidelines; Immunization; Intra-amniotic infection.

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Conflict of interest statement

Nicola Klein reports research support from GlaxoSmithKline, Pfizer, Sanofi Pasteur, Merck & Co and Protein Science (now Sanofi Pasteur). Kevin Ault is on several data and safety committees for maternal immunization and drug treatment trials.

Figures

**Fig. 1**
Placental anatomy in the context of intra-amniotic infections (See Section 1.3.4c). Reprinted with permission from Goldenberg RL, Hauth JC, Andrews WW. Intrauterine infection and preterm delivery. N Engl J Med. 2000 May 18;342(20):1500–7 .

**Fig. 2**
Flow diagram describing pathway for source identification.

**Fig. 3**
Definitions synthesized for chorioamnionitis based on the systematic literature review. (Two definitions for clinical chorioamnionitis were developed to correlate with the more specific definition for intraamniotic infection (or “Triple I”) from the NICHD chorioamnionitis workship (Clinical definition A), and with the more sensitive Gibbs criteria for chorioamnioitis (Clinical definition B). Please see Section 1.3.4 for further details.)

**Fig. 4**
Case definition for chorioamnionitis with levels 1–3 of certainty.

See this image and copyright information in PMC

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References

1. Higgins R.D., Saade G., Polin R.A., Grobman W.A., Buhimschi I.A., Watterberg K. Evaluation and management of women and newborns with a maternal diagnosis of chorioamnionitis: summary of a workshop. Obstet Gynecol. 2016;127(3):426–436. - PMC - PubMed
1. Tita A.T., Andrews W.W. Diagnosis and management of clinical chorioamnionitis. Clin Perinatol. 2010;37(2):339–354. - PMC - PubMed
1. Ogunyemi D., Murillo M., Jackson U., Hunter N., Alperson B. The relationship between placental histopathology findings and perinatal outcome in preterm infants. J Matern Fetal Neonatal Med. 2003;13(2):102–109. - PubMed
1. Gibbs R.S., Duff P. Progress in pathogenesis and management of clinical intraamniotic infection. Am J Obstet Gynecol. 1991;164(5 Pt 1):1317–1326. - PubMed
1. Soper D.E., Mayhall C.G., Dalton H.P. Risk factors for intraamniotic infection: a prospective epidemiologic study. Am J Obstet Gynecol. 1989;161(3):562–566. discussion 6–8. - PubMed

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[1] Higgins R.D., Saade G., Polin R.A., Grobman W.A., Buhimschi I.A., Watterberg K. Evaluation and management of women and newborns with a maternal diagnosis of chorioamnionitis: summary of a workshop. Obstet Gynecol. 2016;127(3):426–436. - PMC - PubMed

[2] Higgins R.D., Saade G., Polin R.A., Grobman W.A., Buhimschi I.A., Watterberg K. Evaluation and management of women and newborns with a maternal diagnosis of chorioamnionitis: summary of a workshop. Obstet Gynecol. 2016;127(3):426–436. - PMC - PubMed

[3] Tita A.T., Andrews W.W. Diagnosis and management of clinical chorioamnionitis. Clin Perinatol. 2010;37(2):339–354. - PMC - PubMed

[4] Tita A.T., Andrews W.W. Diagnosis and management of clinical chorioamnionitis. Clin Perinatol. 2010;37(2):339–354. - PMC - PubMed

[5] Ogunyemi D., Murillo M., Jackson U., Hunter N., Alperson B. The relationship between placental histopathology findings and perinatal outcome in preterm infants. J Matern Fetal Neonatal Med. 2003;13(2):102–109. - PubMed

[6] Ogunyemi D., Murillo M., Jackson U., Hunter N., Alperson B. The relationship between placental histopathology findings and perinatal outcome in preterm infants. J Matern Fetal Neonatal Med. 2003;13(2):102–109. - PubMed

[7] Gibbs R.S., Duff P. Progress in pathogenesis and management of clinical intraamniotic infection. Am J Obstet Gynecol. 1991;164(5 Pt 1):1317–1326. - PubMed

[8] Gibbs R.S., Duff P. Progress in pathogenesis and management of clinical intraamniotic infection. Am J Obstet Gynecol. 1991;164(5 Pt 1):1317–1326. - PubMed

[9] Soper D.E., Mayhall C.G., Dalton H.P. Risk factors for intraamniotic infection: a prospective epidemiologic study. Am J Obstet Gynecol. 1989;161(3):562–566. discussion 6–8. - PubMed

[10] Soper D.E., Mayhall C.G., Dalton H.P. Risk factors for intraamniotic infection: a prospective epidemiologic study. Am J Obstet Gynecol. 1989;161(3):562–566. discussion 6–8. - PubMed

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Chorioamnionitis: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data

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Chorioamnionitis: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data

Authors

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Conflict of interest statement

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