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. 2020 Feb;47(2):1099-1106.
doi: 10.1007/s11033-019-05206-7. Epub 2019 Nov 29.

Molecular characterization of the Krüppel-homolog 1 and its role in ovarian development in Sogatella furcifera (Hemiptera: Delphacidae)

Kui Hu  1 , Ping Tian  1 , Lu Yang  1 , Yan Tang  1 , Lin Qiu  1 , Hualiang He  1 , Wenbing Ding  2   3 , Youzhi Li  4   5
Affiliations

Molecular characterization of the Krüppel-homolog 1 and its role in ovarian development in Sogatella furcifera (Hemiptera: Delphacidae)

Kui Hu et al. Mol Biol Rep. 2020 Feb.

Abstract

Juvenile hormone (JH) plays a pivotal role in insect reproduction. The Krüppel-homolog 1 (Kr-h1) is a JH-inducible zinc finger transcription factor that has also been found to play a role in insect reproduction, however, its function varies across species. In this study, we cloned SfKr-h1 from Sogatella furcifera and investigated its role in ovarian development. The open reading frame of SfKr-h1 is 1 800 bp encoding 599 amino acids. The putative amino acid sequence of SfKr-h1 contains eight putative C2H2-type zinc finger domains and is highly homologous with the Kr-h1s of other hemipteran species. Expression of SfKr-h1 peaked 96 h after adult emergence and was highest in the ovary. RNA interference (RNAi) knockdown of SfKr-h1 substantially reduced the transcription of SfVg, and arrested ovarian development. These results suggest that SfKr-h1 is critical for normal ovarian development in S. furcifera.

Keywords: Juvenile hormone; Krüppel-homolog 1; RNA interference; Reproduction; Sogatella furcifera.

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