Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2019 Nov 29;11(23):10783-10785.
doi: 10.18632/aging.102504. Epub 2019 Nov 29.

CX3CL1 intracellular domain and adult neurogenesis

Marc R Benoit  1 , Manoshi Gayen  1 , Riqiang Yan  1
Affiliations
Editorial

CX3CL1 intracellular domain and adult neurogenesis

Marc R Benoit et al. Aging (Albany NY). .
No abstract available

Keywords: Alzheimer’s disease; CX3CL1; adult neurogenesis; fractalkine.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Full length CX3CL1 containing a signal peptide sequence (grey), extracellular C-X-X-X-C domain (blue), and C-terminal fragment (CX3CL1-ct), which includes transmembrane domain (dark blue) and a short intracellular domain (purple, CX3CL1-ICD), released after cleavages by α-, β- and γ-secretases. Nuclear localization of CX3CL1-ICD triggers gene expression that may induce upregulation of survival genes, leading to increased adult neurogenesis, rescued neuronal loss and reduced amyloid deposition in 5xFAD mouse models of Alzheimer’s disease.
See this image and copyright information in PMC

References

    1. Gage FH. Science. 2019; 364:827–28. 10.1126/science.aav6885 - DOI - PubMed
    1. Fan Q, et al. J Exp Med. 2019; 216:1891–903. 10.1084/jem.20182238 - DOI - PMC - PubMed
    1. Lee S, et al. J Neurosci. 2014; 34:12538–46. 10.1523/JNEUROSCI.0853-14.2014 - DOI - PMC - PubMed
    1. Lee S, et al. Am J Pathol. 2010; 177:2549–62. 10.2353/ajpath.2010.100265 - DOI - PMC - PubMed
    1. Fuhrmann M, et al. Nat Neurosci. 2010; 13:411–13. 10.1038/nn.2511 - DOI - PMC - PubMed

Publication types