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. 2019 Dec 2;26(1):94.
doi: 10.1186/s12929-019-0587-9.

The functional roles of IGF-1 variants in the susceptibility and clinical outcomes of mild traumatic brain injury

Yu-Jia Wang  1 , Henry Sung-Ching Wong  2 , Chung-Che Wu  3   4 , Yung-Hsiao Chiang  3   4 , Wen-Ta Chiu  5 , Kai-Yun Chen  6 , Wei-Chiao Chang  7   8   9   10   11
Affiliations

The functional roles of IGF-1 variants in the susceptibility and clinical outcomes of mild traumatic brain injury

Yu-Jia Wang et al. J Biomed Sci. .

Abstract

Background: Insulin-like growth factor 1 (IGF-1) is an important pleiotropic hormone that exerts neuroprotective and neuroreparative effects after a brain injury. However, the roles of IGF-1 variants in mild traumatic brain injury (mTBI) are not yet fully understood. This study attempted to elucidate the effects of IGF-1 variants on the risk and neuropsychiatric outcomes of mTBI.

Methods: Based on 176 recruited mTBI patients and 1517 control subjects from the Taiwan Biobank project, we first compared the genotypic distributions of IGF-1 variants between the two groups. Then, we analyzed associations of IGF-1 variants with neuropsychiatric symptoms after mTBI, including anxiety, depression, dizziness, and sleep disturbances. Functional annotation of IGF-1 variants was also performed through bioinformatics databases.

Results: The minor allele of rs7136446 was over-represented in mTBI patients compared to community-based control subjects. Patients carrying minor alleles of rs7136446 and rs972936 showed more dizziness and multiple neuropsychiatric symptoms after brain injury.

Conclusions: IGF-1 variants were associated with the risk and neuropsychiatric symptoms of mTBI. The findings highlight the important role of IGF-1 in the susceptibility and clinical outcomes of mTBI.

Keywords: Anxiety; Depression; Dizziness; Genetic variants; Insulin-like growth factor 1; Mild traumatic brain injury; Sleep disorders.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Graphical overview of the genotyped IGF-1 gene
See this image and copyright information in PMC

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