This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

Editorial

. 2019 Dec;104(12):2325-2327.

doi: 10.3324/haematol.2019.230904.

A new target for fetal hemoglobin reactivation

Angela Rivers^{1

2}, Robert Molokie^{2

3}, Donald Lavelle^{4

3}

Affiliations

Affiliations

¹ Department of Pediatrics, University of Illinois at Chicago.
² Jesse Brown VA Medical Center.
³ Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
⁴ Jesse Brown VA Medical Center dlavelle@uic.edu.

PMID: 31787612
PMCID: PMC6959183
DOI: 10.3324/haematol.2019.230904

Editorial

A new target for fetal hemoglobin reactivation

Angela Rivers et al. Haematologica. 2019 Dec.

. 2019 Dec;104(12):2325-2327.

doi: 10.3324/haematol.2019.230904.

Authors

Angela Rivers^{1

2}, Robert Molokie^{2

3}, Donald Lavelle^{4

3}

Affiliations

¹ Department of Pediatrics, University of Illinois at Chicago.
² Jesse Brown VA Medical Center.
³ Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
⁴ Jesse Brown VA Medical Center dlavelle@uic.edu.

PMID: 31787612
PMCID: PMC6959183
DOI: 10.3324/haematol.2019.230904

No abstract available

PubMed Disclaimer

Figures

Figure 1. — Figure 1.
Repression of the γ-globin gene by MBD2. (A) Contrasting effect of deletions of MBD2 and MBD3 on fetal hemoglobin (HbF). (B) Amino acid substitutions within the intrinsically disordered region (IDR) and coiled-coiled (CC) domains of MBD2 disrupt interactions with components of the NURD co-repressor and fail to repress HbF in MBD2 knockout cells.

See this image and copyright information in PMC

Comment on

Disruption of the MBD2-NuRD complex but not MBD3-NuRD induces high level HbF expression in human adult erythroid cells.
Yu X, Azzo A, Bilinovich SM, Li X, Dozmorov M, Kurita R, Nakamura Y, Williams DC Jr, Ginder GD. Yu X, et al. Haematologica. 2019 Dec;104(12):2361-2371. doi: 10.3324/haematol.2018.210963. Epub 2019 Apr 19. Haematologica. 2019. PMID: 31004025 Free PMC article.

Similar articles

Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.
Sankaran VG, Menne TF, Xu J, Akie TE, Lettre G, Van Handel B, Mikkola HK, Hirschhorn JN, Cantor AB, Orkin SH. Sankaran VG, et al. Science. 2008 Dec 19;322(5909):1839-42. doi: 10.1126/science.1165409. Epub 2008 Dec 4. Science. 2008. PMID: 19056937
Role of intergenic human gamma-delta-globin sequences in human hemoglobin switching and reactivation of fetal hemoglobin in adult erythroid cells.
Bank A, O'Neill D, Lopez R, Pulte D, Ward M, Mantha S, Richardson C. Bank A, et al. Ann N Y Acad Sci. 2005;1054:48-54. doi: 10.1196/annals.1345.057. Ann N Y Acad Sci. 2005. PMID: 16339651 Review.
Reactivation of Fetal Hemoglobin for Treating β-Thalassemia and Sickle Cell Disease.
Cui S, Engel JD. Cui S, et al. Adv Exp Med Biol. 2017;1013:177-202. doi: 10.1007/978-1-4939-7299-9_7. Adv Exp Med Biol. 2017. PMID: 29127681
The regulatory role of the adrenergic agonists phenylephrine and isoproterenol on fetal hemoglobin expression and erythroid differentiation.
Mei Y, Yin N, Jin X, He J, Yin Z. Mei Y, et al. Endocrinology. 2013 Dec;154(12):4640-9. doi: 10.1210/en.2013-1535. Epub 2013 Sep 30. Endocrinology. 2013. PMID: 24080366
[Regulation of chromatin and transcription by methyl-CpG binding proteins].
Nakao M, Matsui S, Yamamoto S, Fujita N. Nakao M, et al. Seikagaku. 2000 Dec;72(12):1425-30. Seikagaku. 2000. PMID: 11201105 Review. Japanese. No abstract available.

See all similar articles

Cited by

Targeting Genetic Modifiers of HBG Gene Expression in Sickle Cell Disease: The miRNA Option.
Starlard-Davenport A, Gu Q, Pace BS. Starlard-Davenport A, et al. Mol Diagn Ther. 2022 Sep;26(5):497-509. doi: 10.1007/s40291-022-00589-z. Epub 2022 May 12. Mol Diagn Ther. 2022. PMID: 35553407 Free PMC article. Review.
Exploring epigenetic and microRNA approaches for γ-globin gene regulation.
Starlard-Davenport A, Fitzgerald A, Pace BS. Starlard-Davenport A, et al. Exp Biol Med (Maywood). 2021 Nov;246(22):2347-2357. doi: 10.1177/15353702211028195. Epub 2021 Jul 22. Exp Biol Med (Maywood). 2021. PMID: 34292080 Free PMC article. Review.
Gene Editing-Based Technologies for Beta-hemoglobinopathies Treatment.
Rahimmanesh I, Boshtam M, Kouhpayeh S, Khanahmad H, Dabiri A, Ahangarzadeh S, Esmaeili Y, Bidram E, Vaseghi G, Haghjooy Javanmard S, Shariati L, Zarrabi A, Varma RS. Rahimmanesh I, et al. Biology (Basel). 2022 Jun 4;11(6):862. doi: 10.3390/biology11060862. Biology (Basel). 2022. PMID: 35741383 Free PMC article. Review.
Genome editing strategies for fetal hemoglobin induction in beta-hemoglobinopathies.
Demirci S, Leonard A, Tisdale JF. Demirci S, et al. Hum Mol Genet. 2020 Sep 30;29(R1):R100-R106. doi: 10.1093/hmg/ddaa088. Hum Mol Genet. 2020. PMID: 32406490 Free PMC article. Review.
Epigenetic activities in erythroid cell gene regulation.
Wang Y, Yu L, Engel JD, Singh SA. Wang Y, et al. Semin Hematol. 2021 Jan;58(1):4-9. doi: 10.1053/j.seminhematol.2020.11.007. Epub 2020 Dec 15. Semin Hematol. 2021. PMID: 33509442 Free PMC article.

See all "Cited by" articles

References

1. Piel FB, Steinberg MH, Rees DC. Sickle Cell Disease. N Engl J Med. 2017;376(16):1561–1573. - PubMed
1. Modell B, Darlison M. Global epidemiology of haemoglobin disorders and derived service indicators. Bull World health Organ. 2008;86(6):480–487. - PMC - PubMed
1. Ginder GD. Epigenetic regulation of fetal globin gene expression in adult erythroid cells. Transl Res. 2015;165(1):115–125. - PMC - PubMed
1. Suzuki M, Yamamoto M, Engel JD. Fetal globin gene repressors as drug targets for molecular therapies to treat the β-globinopathies. Mol Cell Biol. 2014;34(19):3560–3569. - PMC - PubMed
1. Lavelle D, Engel JD, Saunthararajah Y. Fetal hemoglobin induction by epigenetic drugs. Semin Hematol. 2018;55(2):60–67. - PMC - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions

Grants and funding

P01 HL146372/HL/NHLBI NIH HHS/United States

LinkOut - more resources

Full Text Sources
Research Materials
- National BioResource Project