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Case Reports
. 2019 Sep 27;7(11):2135-2139.
doi: 10.1002/ccr3.2456. eCollection 2019 Nov.

Infliximab-induced autoimmune hepatitis requiring liver transplantation

Frederick Wong  1 , Bashaar Al Ibrahim  1   2 , Joanna Walsh  3 , Karim Qumosani  1
Affiliations
Case Reports

Infliximab-induced autoimmune hepatitis requiring liver transplantation

Frederick Wong et al. Clin Case Rep. .

Abstract

Autoimmune hepatitis is an infrequent but significant side effect of infliximab treatment. Diagnosis of autoimmune hepatitis is based on clinical, laboratory, and histological findings. Initial treatment involves cessation of infliximab and trial of prednisone. We present a rare case of infliximab-induced autoimmune hepatitis leading to liver failure requiring transplantation.

Keywords: Crohn's disease; autoimmune hepatitis; infliximab; liver transplantation.

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Conflict of interest statement

The authors do not have any conflicts of interest to declare.

Figures

Figure 1
Figure 1
Liver biopsy revealing (A) acute hepatitis with parenchymal necrosis (H&E, 4×), B,Hepatocyte injury and apoptosis with dense plasma cell infiltrate (H&E, 20×). C, Interface hepatitis with plasma cells (H&E, 10×)
Figure 2
Figure 2
Clinical course since admission
Figure 3
Figure 3
Liver explant (A) parenchymal collapse (H&E, 10×). B, Parenchymal collapse (reticulin, 10×).C, Portal plasma cells (H&E, 20×)
See this image and copyright information in PMC

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