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- PMID: 31790021
- DOI: 10.1097/HJH.0000000000002219
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Allopurinol treatment adversely impacts left ventricular mass regression in patients with well-controlled hypertension.J Hypertens. 2019 Dec;37(12):2481-2489. doi: 10.1097/HJH.0000000000002189. J Hypertens. 2019. PMID: 31268872 Free PMC article. Clinical Trial.
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Adverse cardiovascular effects of allopurinol are related to the use of high doses.J Hypertens. 2020 Jan;38(1):176-177. doi: 10.1097/HJH.0000000000002218. J Hypertens. 2020. PMID: 31790020 No abstract available.
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- George J, Carr E, Davies J, Belch JJ, Struthers A. High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid. Circulation 2006; 114:2508–2516.
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- Rajendra NS, Ireland S, George J, Belch JJ, Lang CC, Struthers AD. Mechanistic insights into the therapeutic use of high-dose allopurinol in angina pectoris. J Am Coll Cardiol 2011; 58:820–828.
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- Ogino K, Kato M, Furuse Y, Kinugasa Y, Ishida K, Osaki S, et al. Uric acid-lowering treatment with benzbromarone in patients with heart failure: a double-blind placebo-controlled crossover preliminary study. Circ Heart Fail 2010; 3:73–81.
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- Farquharson CA, Butler R, Hill A, Belch JJ, Struthers AD. Allopurinol improves endothelial dysfunction in chronic heart failure. Circulation 2002; 106:221–226.
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