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. 2019 Dec 28;55(100):15145-15148.
doi: 10.1039/c9cc08463k. Epub 2019 Dec 2.

A lipase-responsive antifungal nanoplatform for synergistic photodynamic/photothermal/pharmaco-therapy of azole-resistant Candida albicans infections

Dongliang Yang  1 , Xinyi Lv  1 , Lei Xue  1 , Nan Yang  1 , Yanling Hu  2 , Lixing Weng  3 , Nina Fu  3 , Lianhui Wang  3 , Xiaochen Dong  4
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A lipase-responsive antifungal nanoplatform for synergistic photodynamic/photothermal/pharmaco-therapy of azole-resistant Candida albicans infections

Dongliang Yang et al. Chem Commun (Camb). .

Abstract

A lipase-triggered drug release nanoplatform (PGL-DPP-FLU NPs) for multi-modal antifungal therapy is developed. The lipases secreted by C. albicans can accelerate FLU release. The ROS and heat produced by PGL-DPP-FLU NPs make C. albicans more vulnerable to FLU, thereby PGL-DPP-FLU NPs exhibit high performance for combating azole-resistant C. albicans biofilms and wound infection.

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