Impact of oral COMT-inhibitors on gut microbiota and short chain fatty acids in Parkinson's disease

Affiliations

¹ Department of Neurology, Saarland University Medical Center, Homburg, Germany, Kirrberger Str., 66421, Homburg, Germany. Electronic address: daniel.gruen@uks.eu.
² Department of Neurology, Saarland University Medical Center, Homburg, Germany, Kirrberger Str., 66421, Homburg, Germany. Electronic address: valerie.zimmer@uks.eu.
³ Department of Neurology, Saarland University Medical Center, Homburg, Germany, Kirrberger Str., 66421, Homburg, Germany. Electronic address: jil.kauffmann@uks.eu.
⁴ Department of Neurology, Saarland University Medical Center, Homburg, Germany, Kirrberger Str., 66421, Homburg, Germany. Electronic address: joerg.spiegel@uks.eu.
⁵ Department of Neurology, Saarland University Medical Center, Homburg, Germany, Kirrberger Str., 66421, Homburg, Germany. Electronic address: ulrich.dillmann@uks.eu.
⁶ Institute of Microecology, Herborn, Germany, Auf Den Lüppen 8, 35745, Herborn, Germany. Electronic address: andreas.schwiertz@microoek.de.
⁷ Department of Neurology, Saarland University Medical Center, Homburg, Germany, Kirrberger Str., 66421, Homburg, Germany. Electronic address: klaus.fassbender@uks.eu.
⁸ Department of Neurology, Saarland University Medical Center, Homburg, Germany, Kirrberger Str., 66421, Homburg, Germany. Electronic address: mathias.fousse@uks.eu.
⁹ Department of Neurology, Saarland University Medical Center, Homburg, Germany, Kirrberger Str., 66421, Homburg, Germany. Electronic address: marcus.unger@uks.eu.

Daniel Grün et al. Parkinsonism Relat Disord. 2020 Jan.

. 2020 Jan:70:20-22.

doi: 10.1016/j.parkreldis.2019.11.020. Epub 2019 Nov 25.

¹ Department of Neurology, Saarland University Medical Center, Homburg, Germany, Kirrberger Str., 66421, Homburg, Germany. Electronic address: daniel.gruen@uks.eu.
² Department of Neurology, Saarland University Medical Center, Homburg, Germany, Kirrberger Str., 66421, Homburg, Germany. Electronic address: valerie.zimmer@uks.eu.
³ Department of Neurology, Saarland University Medical Center, Homburg, Germany, Kirrberger Str., 66421, Homburg, Germany. Electronic address: jil.kauffmann@uks.eu.
⁴ Department of Neurology, Saarland University Medical Center, Homburg, Germany, Kirrberger Str., 66421, Homburg, Germany. Electronic address: joerg.spiegel@uks.eu.
⁵ Department of Neurology, Saarland University Medical Center, Homburg, Germany, Kirrberger Str., 66421, Homburg, Germany. Electronic address: ulrich.dillmann@uks.eu.
⁶ Institute of Microecology, Herborn, Germany, Auf Den Lüppen 8, 35745, Herborn, Germany. Electronic address: andreas.schwiertz@microoek.de.
⁷ Department of Neurology, Saarland University Medical Center, Homburg, Germany, Kirrberger Str., 66421, Homburg, Germany. Electronic address: klaus.fassbender@uks.eu.
⁸ Department of Neurology, Saarland University Medical Center, Homburg, Germany, Kirrberger Str., 66421, Homburg, Germany. Electronic address: mathias.fousse@uks.eu.
⁹ Department of Neurology, Saarland University Medical Center, Homburg, Germany, Kirrberger Str., 66421, Homburg, Germany. Electronic address: marcus.unger@uks.eu.

No abstract available

Keywords: COMT-Inhibitor; Faecalibacterium prausnitzii; Fecal butyrate; Gut microbiota; Parkinson's disease.

Conflict of interest statement

Declaration of competing interest M.M.U. and D.G. were supported with an unrestricted grant from BIAL – PORTELA & C(a), S.A., Portugal.