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. 2019;119(10):111-120.
doi: 10.17116/jnevro2019119101111.

[Modern concepts of pathogenetic therapy of anxiety disorders]

[Article in Russian]
O V Grigorova  1 , R V Akhapkin  1 , Yu A Aleksandrovsky  1
Affiliations

[Modern concepts of pathogenetic therapy of anxiety disorders]

[Article in Russian]
O V Grigorova et al. Zh Nevrol Psikhiatr Im S S Korsakova. 2019.

Abstract
in English, Russian

The high prevalence of anxiety disorders around the world leads to a high interest in the study of anxiety. At the moment, a lot of knowledge about the pathogenesis and therapy of anxiety disorders has been accumulated, which is well covered in modern domestic and world medical literature. It is known that many areas of the brain are involved in the modulation of anxiety, among which the amygdala is considered the key in the modulation of anxiety and fear. A large body of evidence supports the involvement of different neurotransmitter systems in the processes of anxiogenesis-anxiolysis (GABA, monoamines, glutamate, neuropeptides, neurosteroids). This article provides an analysis of methods of pharmacological impact on each of these systems, which serve to optimize the already known strategies of anxiolytic therapy.

Большая распространенность тревожных расстройств во всем мире обусловливает повышенный интерес к изучению этой проблемы. В современной отечественной и зарубежной медицинской литературе имеется большое число исследований, касающихся патогенеза и терапии тревожных расстройств. Установлено, что в развитии и модуляции тревоги участвуют многие зоны мозга, среди которых миндалина считается ключевой. Доказано участие различных медиаторных систем в процессах анксиогенеза и анксиолизиса (ГАМК, моноамины, глутамат, нейропептиды, нейростероиды). В настоящем обзоре представлен анализ способов фармакологического воздействия на каждую из перечисленных систем, которые служат оптимизации известных стратегий анксиолитической терапии.

Keywords: GABA; anxiety; anxiolytic drug; dopamine; glutamate; histamine; monoamines; neurobiology of anxiety disorders; neuropeptides; neurosteroids; noradrenaline; pathogenesis of anxiety disorders; serotonin; therapy of anxiety disorders.

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