Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2020 Jan 31;40(1):BSR20193130.
doi: 10.1042/BSR20193130.

Prediabetes predicts adverse cardiovascular outcomes after percutaneous coronary intervention: a meta-analysis

Yong Zhao  1 , Min Guo  2 , Gang Shi  1
Affiliations
Meta-Analysis

Prediabetes predicts adverse cardiovascular outcomes after percutaneous coronary intervention: a meta-analysis

Yong Zhao et al. Biosci Rep. .

Abstract

Background: Prediabetes has been related with increased risk of coronary artery disease (CAD). However, the prognostic efficacy of prediabetes for patients receiving percutaneous coronary intervention (PCI) remains undetermined. We aimed to quantitatively evaluate the influence of diabetes on the risks of major adverse cardiovascular events (MACEs) after PCI in a meta-analysis.

Methods: Longitudinal follow-up studies evaluating the association between prediabetes and risks of MACEs and mortality after PCI were identified by search of PubMed and Embase databases. A random-effect model was applied to pool the results. Subgroup analyses were performed to evaluate the impacts of study characteristics on the outcome.

Results: Twelve follow-up studies including 10,048 patients that underwent PCI were included. Compared with patients with normoglycemia at admission, those with prediabetes were had significantly higher risk MACEs during follow-up (adjusted risk ratio [RR]: 1.53, 95% confidence interval [CI]: 1.25-1.87, P < 0.001). Further subgroup analyses indicated that the association between prediabetes and higher risk of MACEs remained regardless of the study design, sample size, CAD subtype, PCI type, definition of diabetes, or follow-up duration. Moreover, patients with prediabetes had higher significantly risk of MACEs in studies with adjustment of coronary lesion severity (RR: 1.79, P < 0.001), but the association became insignificant in studies without adjustment of the coronary lesion severity (RR: 1.23, P = 0.09).

Conclusions: Prediabetes is independently associated with increased risk of MACEs after PCI as compared with those with normoglycemia, even in studies with adjustment of coronary severity.

Keywords: coronary artery disease; major adverse cardiovascular events; meta-analysis; percutaneous coronary intervention; prediabetes.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there are no competing interests associated with the manuscript.

Figures

Figure 1
Figure 1. Flowchart of database search and study identification
Figure 2
Figure 2. Forest plots for the meta-analysis of the incidence of MACE in patients with prediabetes compared to those with normoglycemia after PCI
Figure 3
Figure 3. Funnel plots for the meta-analysis
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Szuszkiewicz-Garcia M.M. and Davidson J.A. (2014) Cardiovascular disease in diabetes mellitus: risk factors and medical therapy. Endocrinol. Metab. Clin. North Am. 43, 25–40 10.1016/j.ecl.2013.09.001 - DOI - PubMed
    1. Balakumar P., Maung U.K. and Jagadeesh G. (2016) Prevalence and prevention of cardiovascular disease and diabetes mellitus. Pharmacol. Res. 113, 600–609 10.1016/j.phrs.2016.09.040 - DOI - PubMed
    1. Standl E., Schnell O., McGuire D.K., Ceriello A. and Ryden L. (2017) Integration of recent evidence into management of patients with atherosclerotic cardiovascular disease and type 2 diabetes. Lancet Diabetes Endocrinol. 5, 391–402 10.1016/S2213-8587(17)30033-5 - DOI - PubMed
    1. Rosenzweig J.L., Bakris G.L., Berglund L.F. et al. . (2019) Primary Prevention of ASCVD and T2DM in Patients at Metabolic Risk: An Endocrine Society* Clinical Practice Guideline. J. Clin. Endocrinol. Metab. 10.1210/jc.2019-01338 - DOI - PubMed
    1. Zhuo X., Zhang C., Feng J., Ouyang S., Niu P. and Dai Z. (2019) In-hospital, short-term and long-term adverse clinical outcomes observed in patients with type 2 diabetes mellitus vs non-diabetes mellitus following percutaneous coronary intervention: A meta-analysis including 139,774 patients. Medicine (Baltimore). 98, e14669 10.1097/MD.0000000000014669 - DOI - PMC - PubMed