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Review
. 2019 Nov 28;20(23):6008.
doi: 10.3390/ijms20236008.

Cytokines in Inflammatory Disease

Shinwan Kany  1   2 , Jan Tilmann Vollrath  3 , Borna Relja  1
Affiliations
Review

Cytokines in Inflammatory Disease

Shinwan Kany et al. Int J Mol Sci. .

Abstract

This review aims to briefly discuss a short list of a broad variety of inflammatory cytokines. Numerous studies have implicated that inflammatory cytokines exert important effects with regard to various inflammatory diseases, yet the reports on their specific roles are not always consistent. They can be used as biomarkers to indicate or monitor disease or its progress, and also may serve as clinically applicable parameters for therapies. Yet, their precise role is not always clearly defined. Thus, in this review, we focus on the existing literature dealing with the biology of cytokines interleukin (IL)-6, IL-1, IL-33, tumor necrosis factor-alpha (TNF-α), IL-10, and IL-8. We will briefly focus on the correlations and role of these inflammatory mediators in the genesis of inflammatory impacts (e.g., shock, trauma, immune dysregulation, osteoporosis, and/or critical illness).

Keywords: disease; inflammation; interleukin.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
A schematic representation of various cells expressing different cytokines. Interleukin (IL), Natural killer cells (NK), Tumor necrosis factor-alpha (TNF-α).
See this image and copyright information in PMC

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