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. 2019 Nov;24(48):1900720.
doi: 10.2807/1560-7917.ES.2019.24.48.1900720.

Influenza imprinting in childhood and the influence on vaccine response later in life

Alyson A Kelvin  1   2 , Maria Zambon  3
Affiliations

Influenza imprinting in childhood and the influence on vaccine response later in life

Alyson A Kelvin et al. Euro Surveill. 2019 Nov.
No abstract available

Keywords: Antibody; Glycosylation; Imprinting; Influenza; Pre-existing immunity; Vaccine effectiveness.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
Influenza imprinting, immune refinement, and imprint-regulated effect of vaccine (I-REV)
See this image and copyright information in PMC

References

    1. Francis ME, King ML, Kelvin AA. Back to the Future for Influenza Preimmunity-Looking Back at Influenza Virus History to Infer the Outcome of Future Infections. Viruses. 2019;11(2):E122. 10.3390/v11020122 - DOI - PMC - PubMed
    1. Gostic KM, Ambrose M, Worobey M, Lloyd-Smith JO. Potent protection against H5N1 and H7N9 influenza via childhood hemagglutinin imprinting. Science. 2016;354(6313):722-6. 10.1126/science.aag1322 - DOI - PMC - PubMed
    1. Skowronski DM, Sabaiduc S, Leir S, Rose C, Zou M, Murti M, et al. Paradoxical clade- and age-specific vaccine effectiveness during the 2018/19 influenza A(H3N2) epidemic in Canada: potential imprint-regulated effect of vaccine (I-REV). Euro Surveill. 2019;24(46). 10.2807/1560-7917.ES.2019.24.46.1900585 - DOI - PMC - PubMed
    1. Kissling E, Pozo F, Buda S, Vilcu AM, Gherasim A, Brytting M, et al. Low 2018/19 vaccine effectiveness against influenza A(H3N2) among 15-64-year-olds in Europe: exploration by birth cohort. Euro Surveill. 2019;24(48):. 1900604. - PMC - PubMed
    1. Francis TJ. On the Doctrine of Original Antigenic Sin. Proc Am Philos Soc. 1960;104:572-8.

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