Sebaceous carcinoma: evidence-based clinical practice guidelines

Joshua L Owen¹, Nour Kibbi², Brandon Worley³, Ryan C Kelm¹, Jordan V Wang⁴, Christopher A Barker⁵, Ramona Behshad⁶, Christopher K Bichakjian⁷, Diana Bolotin⁸, Jeremy S Bordeaux⁹, Scott H Bradshaw¹⁰, Todd V Cartee¹¹, Sunandana Chandra¹², Nancy L Cho¹³, Jennifer N Choi¹, M Laurin Council¹⁴, Hakan Demirci¹⁵, Daniel B Eisen¹⁶, Bita Esmaeli¹⁷, Nicholas Golda¹⁸, Conway C Huang¹⁹, Sherrif F Ibrahim²⁰, S Brian Jiang²¹, John Kim²², Timothy M Kuzel²³, Stephen Y Lai²⁴, Naomi Lawrence²⁵, Erica H Lee²⁶, Justin J Leitenberger²⁷, Ian A Maher²⁸, Margaret W Mann²⁹, Kira Minkis³⁰, Bharat B Mittal³¹, Kishwer S Nehal²⁶, Isaac M Neuhaus³², David M Ozog³³, Brian Petersen³⁴, Veronica Rotemberg²⁶, Sandeep Samant³⁵, Faramarz H Samie³⁶, Sabah Servaes³⁷, Carol L Shields³⁸, Thuzar M Shin³⁹, Joseph F Sobanko³⁹, Ally-Khan Somani⁴⁰, William G Stebbins⁴¹, J Regan Thomas³⁵, Valencia D Thomas⁴², David T Tse⁴³, Abigail H Waldman⁴⁴, Michael K Wong⁴⁵, Y Gloria Xu⁴⁶, Siegrid S Yu³², Nathalie C Zeitouni⁴⁷, Timothy Ramsay⁴⁸, Kelly A Reynolds¹, Emily Poon¹, Murad Alam⁴⁹

Affiliations

¹ Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
² Department of Dermatology, Yale School of Medicine, New Haven, CT, USA.
³ Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Division of Dermatology, The Ottawa Hospital, Ottawa, ON, Canada.
⁴ Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, USA.
⁵ Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
⁶ Department of Dermatology, Saint Louis University School of Medicine, Saint Louis, MO, USA.
⁷ Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.
⁸ Section of Dermatology, The University of Chicago, Chicago, IL, USA.
⁹ Department of Dermatology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
¹⁰ Department of Pathology and Laboratory Medicine, The Ottawa Hospital, Ottawa, ON, Canada.
¹¹ Division of Dermatology, Pennsylvania State University, Hershey, PA, USA.
¹² Division of Hematology and Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
¹³ Department of Surgery, Brigham and Women's Hospital, Harvard University, Boston, MA, USA.
¹⁴ Division of Dermatology, Center for Dermatologic and Cosmetic Surgery, Washington University in Saint Louis, Saint Louis, MO, USA.
¹⁵ Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, MI, USA.
¹⁶ Department of Dermatology, University of California Davis, Sacramento, CA, USA.
¹⁷ Orbital Oncology and Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
¹⁸ Department of Dermatology, University of Missouri School of Medicine, Columbia, MO, USA.
¹⁹ Department of Dermatology, University of Alabama, Birmingham, AL, USA.
²⁰ Department of Dermatology, University of Rochester, Rochester, NY, USA.
²¹ Department of Dermatology, University of California San Diego, San Diego, CA, USA.
²² Department of Plastic Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
²³ Division of Hematology, Oncology and Cell Therapy, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA.
²⁴ Departments of Head and Neck Surgery and Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
²⁵ Department of Dermatology, Cooper Hospital, Rowan University, Camden, NJ, USA.
²⁶ Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
²⁷ Department of Dermatology, Oregon Health and Science University, Portland, OR, USA.
²⁸ Department of Dermatology, University of Minnesota, Minneapolis, MN, USA.
²⁹ Department of Dermatology, University Hospital, Cleveland, OH, USA.
³⁰ Department of Dermatology, Weill-Cornell Medical College, New York, NY, USA.
³¹ Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
³² Department of Dermatology, University of California at San Francisco, San Francisco, CA, USA.
³³ Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA.
³⁴ Department of Dermatology, Colorado Permanente Medical Group, Denver, CO, USA.
³⁵ Department of Otolaryngology-Head and Neck Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
³⁶ Department of Dermatology, Columbia University Medical Center, New York, NY, USA.
³⁷ Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.
³⁸ Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.
³⁹ Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
⁴⁰ Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN, USA.
⁴¹ Department of Dermatology, Vanderbilt University Medical Center, Nashville, TN, USA.
⁴² Dermatology and Dermatopathology, Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
⁴³ Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
⁴⁴ Brigham and Women's Hospital Department of Dermatology, Harvard Medical School, Boston, MA, USA.
⁴⁵ Division of Cancer Medicine, Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
⁴⁶ Department of Dermatology, University of Wisconsin-Madison, Madison, WI, USA.
⁴⁷ Department of Dermatology, University of Arizona, Phoenix, AZ, USA.
⁴⁸ The Ottawa Health Research Institute, The Ottawa Hospital, Ottawa, ON, Canada.
⁴⁹ Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address: m-alam@northwestern.edu.

PMID: 31797796
DOI: 10.1016/S1470-2045(19)30673-4

Review

Sebaceous carcinoma: evidence-based clinical practice guidelines

Joshua L Owen et al. Lancet Oncol. 2019 Dec.

. 2019 Dec;20(12):e699-e714.

doi: 10.1016/S1470-2045(19)30673-4.

Authors

Affiliations

¹ Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
² Department of Dermatology, Yale School of Medicine, New Haven, CT, USA.
³ Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Division of Dermatology, The Ottawa Hospital, Ottawa, ON, Canada.
⁴ Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, USA.
⁵ Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
⁶ Department of Dermatology, Saint Louis University School of Medicine, Saint Louis, MO, USA.
⁷ Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.
⁸ Section of Dermatology, The University of Chicago, Chicago, IL, USA.
⁹ Department of Dermatology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
¹⁰ Department of Pathology and Laboratory Medicine, The Ottawa Hospital, Ottawa, ON, Canada.
¹¹ Division of Dermatology, Pennsylvania State University, Hershey, PA, USA.
¹² Division of Hematology and Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
¹³ Department of Surgery, Brigham and Women's Hospital, Harvard University, Boston, MA, USA.
¹⁴ Division of Dermatology, Center for Dermatologic and Cosmetic Surgery, Washington University in Saint Louis, Saint Louis, MO, USA.
¹⁵ Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, MI, USA.
¹⁶ Department of Dermatology, University of California Davis, Sacramento, CA, USA.
¹⁷ Orbital Oncology and Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
¹⁸ Department of Dermatology, University of Missouri School of Medicine, Columbia, MO, USA.
¹⁹ Department of Dermatology, University of Alabama, Birmingham, AL, USA.
²⁰ Department of Dermatology, University of Rochester, Rochester, NY, USA.
²¹ Department of Dermatology, University of California San Diego, San Diego, CA, USA.
²² Department of Plastic Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
²³ Division of Hematology, Oncology and Cell Therapy, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA.
²⁴ Departments of Head and Neck Surgery and Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
²⁵ Department of Dermatology, Cooper Hospital, Rowan University, Camden, NJ, USA.
²⁶ Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
²⁷ Department of Dermatology, Oregon Health and Science University, Portland, OR, USA.
²⁸ Department of Dermatology, University of Minnesota, Minneapolis, MN, USA.
²⁹ Department of Dermatology, University Hospital, Cleveland, OH, USA.
³⁰ Department of Dermatology, Weill-Cornell Medical College, New York, NY, USA.
³¹ Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
³² Department of Dermatology, University of California at San Francisco, San Francisco, CA, USA.
³³ Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA.
³⁴ Department of Dermatology, Colorado Permanente Medical Group, Denver, CO, USA.
³⁵ Department of Otolaryngology-Head and Neck Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
³⁶ Department of Dermatology, Columbia University Medical Center, New York, NY, USA.
³⁷ Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.
³⁸ Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.
³⁹ Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
⁴⁰ Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN, USA.
⁴¹ Department of Dermatology, Vanderbilt University Medical Center, Nashville, TN, USA.
⁴² Dermatology and Dermatopathology, Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
⁴³ Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
⁴⁴ Brigham and Women's Hospital Department of Dermatology, Harvard Medical School, Boston, MA, USA.
⁴⁵ Division of Cancer Medicine, Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
⁴⁶ Department of Dermatology, University of Wisconsin-Madison, Madison, WI, USA.
⁴⁷ Department of Dermatology, University of Arizona, Phoenix, AZ, USA.
⁴⁸ The Ottawa Health Research Institute, The Ottawa Hospital, Ottawa, ON, Canada.
⁴⁹ Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address: m-alam@northwestern.edu.

PMID: 31797796
DOI: 10.1016/S1470-2045(19)30673-4

Abstract

Sebaceous carcinoma usually occurs in adults older than 60 years, on the eyelid, head and neck, and trunk. In this Review, we present clinical care recommendations for sebaceous carcinoma, which were developed as a result of an expert panel evaluation of the findings of a systematic review. Key conclusions were drawn and recommendations made for diagnosis, first-line treatment, radiotherapy, and post-treatment care. For diagnosis, we concluded that deep biopsy is often required; furthermore, differential diagnoses that mimic the condition can be excluded with special histological stains. For treatment, the recommended first-line therapy is surgical removal, followed by margin assessment of the peripheral and deep tissue edges; conjunctival mapping biopsies can facilitate surgical planning. Radiotherapy can be considered for cases with nerve or lymph node involvement, and as the primary treatment in patients who are ineligible for surgery. Post-treatment clinical examination should occur every 6 months for at least 3 years. No specific systemic therapies for advanced disease can be recommended, but targeted therapies and immunotherapies are being developed.

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Sebaceous carcinoma: evidence-based clinical practice guidelines

Affiliations

Sebaceous carcinoma: evidence-based clinical practice guidelines

Authors

Affiliations

Abstract

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Medical