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Review
. 2020 Mar;177(6):1227-1240.
doi: 10.1111/bph.14943. Epub 2020 Feb 6.

Trends in use, pharmacology, and clinical applications of emerging herbal nutraceuticals

Elizabeth M Williamson  1 , Xinmin Liu  2 , Angelo A Izzo  3
Affiliations
Review

Trends in use, pharmacology, and clinical applications of emerging herbal nutraceuticals

Elizabeth M Williamson et al. Br J Pharmacol. 2020 Mar.

Abstract

The nutraceuticals market is vast, encompassing many different products with inconsistent levels of evidence available to support their use. This overview represents a Western perspective of the nutraceuticals market, with a brief comparison with that in China, as an illustration of how individual health supplements increase and decrease in popularity in regional terms. Recent changes in sales patterns, mainly taken from the US market, are summarized and a selection of five newer products, which have not been subject to extensive recent review are profiled: astaxanthin, a carotenoid found in red algae, seafood, salmon and trout, as an antioxidant; cannabidiol, a non-euphoric marijuana ingredient used as mood enhancer and for painful/inflammatory conditions; modified extracts of ginseng used in new indications including dementia and space travel; monk fruit, a non-sugar high intensity sweetener and nigella seed, a popular food ingredient and Asian medicine, which has experienced an extraordinary rise in sales recently. LINKED ARTICLES: This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Different types of products described as “nutraceuticals”
Figure 2
Figure 2
Structure of cis‐ and trans‐isomers of astaxanthin
See this image and copyright information in PMC

References

    1. Agbabiaka, T. B. , Spencer, N. H. , Khanom, S. , & Goodman, C. (2018). Prevalence of drug‐herb and drug‐supplement interactions in older adults: A cross‐sectional survey. The British Journal of General Practice, 68(675), e711–e717. 10.3399/bjgp18X699101 - DOI - PMC - PubMed
    1. Agbabiaka, T. B. , Wider, B. , Watson, L. K. , & Goodman, C. (2017). Concurrent use of prescription drugs and herbal medicinal products in older adults: A systematic review. Drugs & Aging, 34(12), 891–905. 10.1007/s40266-017-0501-7 - DOI - PMC - PubMed
    1. Akhondian, J. , Kianifar, H. , Raoofziaee, M. , Moayedpour, A. , Toosi, M. B. , & Khajedaluee, M. (2011). The effect of thymoquinone on intractable pediatric seizures (pilot study). Epilepsy Research, 93(1), 39–43. 10.1016/j.eplepsyres.2010.10.010 - DOI - PubMed
    1. Alexander, S. P. H. , Kelly, E. , Mathie, A. , Peters, J. A. , Veale, E. L. Armstrong, J. F. , … Davies, J. A. (2019). CGTP Collaborators. THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Introduction andOther Protein Targets. Br J Pharmacol, Suppl 1, S1–S20. 10.1111/bph.14747 - DOI - PMC - PubMed
    1. Alsanad, S. M. , Howard, R. L. , & Williamson, E. M. (2016). An assessment of the impact of herb‐drug combinations used by cancer patients. BMC Complementary and Alternative Medicine, 16, 393 10.1186/s12906-016-1372-x - DOI - PMC - PubMed