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Review
. 2020 Jan 17;15(2):231-241.
doi: 10.1002/asia.201901380. Epub 2019 Dec 18.

Organocatalyzed Synthesis of Functionalized Quinolines

Lian-Hua Li  1 , Zhi-Jie Niu  1 , Yong-Min Liang  1
Affiliations
Review

Organocatalyzed Synthesis of Functionalized Quinolines

Lian-Hua Li et al. Chem Asian J. .

Abstract

As one of the most widely investigated compound skeleton, quinolines possess important medicinal and biological activities. As such, a great number of literatures, including reviews, have reported various methodologies to construct quinolines. Recently, organocatalyzed reactions have attracted the attention of organic chemists due to its being "green" because the reactions avoid the use of toxic metals. In this review, various distinctive contributions are surveyed with specific emphasis on organocatalyzed reactions for quinoline core constructions.

Keywords: metal-free approach; organocatalysis; quinolines; synthetic methods.

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