OPCs on a Diet: A Youthful Serving of Remyelination

Charles W White 3rd¹, Karishma Pratt¹, Saul A Villeda²

Affiliations

¹ Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA; Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
² Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA; Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, San Francisco, CA, USA; Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco, San Francisco, CA, USA; The Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, San Francisco, CA, USA. Electronic address: saul.villeda@ucsf.edu.

PMID: 31801054
DOI: 10.1016/j.cmet.2019.11.009

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OPCs on a Diet: A Youthful Serving of Remyelination

Charles W White 3rd et al. Cell Metab. 2019.

Free article

. 2019 Dec 3;30(6):1004-1006.

doi: 10.1016/j.cmet.2019.11.009.

Authors

Charles W White 3rd¹, Karishma Pratt¹, Saul A Villeda²

Affiliations

¹ Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA; Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
² Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA; Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, San Francisco, CA, USA; Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco, San Francisco, CA, USA; The Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, San Francisco, CA, USA. Electronic address: saul.villeda@ucsf.edu.

PMID: 31801054
DOI: 10.1016/j.cmet.2019.11.009

Abstract

Remyelination declines in the aging central nervous system due to oligodendrocyte precursor cell (OPC) dysfunction. In the latest issue of Cell Stem Cell, Neumann et al. (2019) demonstrate that aged OPCs are amenable to functional rejuvenation by systemic interventions involving alternate-day fasting or treatment with the fasting mimetic metformin.

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Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells.
Neumann B, Baror R, Zhao C, Segel M, Dietmann S, Rawji KS, Foerster S, McClain CR, Chalut K, van Wijngaarden P, Franklin RJM. Neumann B, et al. Cell Stem Cell. 2019 Oct 3;25(4):473-485.e8. doi: 10.1016/j.stem.2019.08.015. Cell Stem Cell. 2019. PMID: 31585093 Free PMC article.

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OPCs on a Diet: A Youthful Serving of Remyelination

Affiliations

OPCs on a Diet: A Youthful Serving of Remyelination

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