Adipose Tissue B Cells Come of Age: The AABs of Fat Inflammation

Saad Khan¹, Sue Tsai², Daniel A Winer³

Affiliations

¹ Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada; Division of Cellular & Molecular Biology, Diabetes Research Group, Toronto General Hospital Research Institute (TGHRI), University Health Network, Toronto, ON M5G 1L7, Canada.
² Department of Medical Microbiology and Immunology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2E1, Canada.
³ Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada; Division of Cellular & Molecular Biology, Diabetes Research Group, Toronto General Hospital Research Institute (TGHRI), University Health Network, Toronto, ON M5G 1L7, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Pathology, University Health Network, Toronto, ON M5G 2C4, Canada; Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA. Electronic address: dwiner@buckinstitute.org.

PMID: 31801058
DOI: 10.1016/j.cmet.2019.11.007

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Adipose Tissue B Cells Come of Age: The AABs of Fat Inflammation

Saad Khan et al. Cell Metab. 2019.

Free article

. 2019 Dec 3;30(6):997-999.

doi: 10.1016/j.cmet.2019.11.007.

Authors

Saad Khan¹, Sue Tsai², Daniel A Winer³

Affiliations

¹ Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada; Division of Cellular & Molecular Biology, Diabetes Research Group, Toronto General Hospital Research Institute (TGHRI), University Health Network, Toronto, ON M5G 1L7, Canada.
² Department of Medical Microbiology and Immunology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2E1, Canada.
³ Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada; Division of Cellular & Molecular Biology, Diabetes Research Group, Toronto General Hospital Research Institute (TGHRI), University Health Network, Toronto, ON M5G 1L7, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Pathology, University Health Network, Toronto, ON M5G 2C4, Canada; Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA. Electronic address: dwiner@buckinstitute.org.

PMID: 31801058
DOI: 10.1016/j.cmet.2019.11.007

Abstract

For nearly a decade, B cells residing locally within the adipose tissue have been linked to the control of metabolic homeostasis. In this issue, Camell et al. (2019) report an expansion of a unique age-associated B cell population in the visceral adipose tissue that regulates insulin resistance and adipose dysfunction during aging.

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Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis.
Camell CD, Günther P, Lee A, Goldberg EL, Spadaro O, Youm YH, Bartke A, Hubbard GB, Ikeno Y, Ruddle NH, Schultze J, Dixit VD. Camell CD, et al. Cell Metab. 2019 Dec 3;30(6):1024-1039.e6. doi: 10.1016/j.cmet.2019.10.006. Epub 2019 Nov 14. Cell Metab. 2019. PMID: 31735593 Free PMC article.

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Adipose Tissue B Cells Come of Age: The AABs of Fat Inflammation

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Adipose Tissue B Cells Come of Age: The AABs of Fat Inflammation

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