Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Practice Guideline
. 2019 Dec 15;59(12):449-491.
doi: 10.2176/nmc.st.2019-0177. Epub 2019 Dec 5.

Guidelines for Intravenous Thrombolysis (Recombinant Tissue-type Plasminogen Activator), the Third Edition, March 2019: A Guideline from the Japan Stroke Society

Kazunori Toyoda  1 , Masatoshi Koga  1 , Yasuyuki Iguchi  2 , Ryo Itabashi  3 , Manabu Inoue  4 , Yasushi Okada  5 , Kuniaki Ogasawara  6 , Akira Tsujino  7 , Yasuhiro Hasegawa  8 , Taketo Hatano  9 , Hiroshi Yamagami  10 , Toru Iwama  11 , Yoshiaki Shiokawa  12 , Yasuo Terayama  13 , Kazuo Minematsu  14
Affiliations
Practice Guideline

Guidelines for Intravenous Thrombolysis (Recombinant Tissue-type Plasminogen Activator), the Third Edition, March 2019: A Guideline from the Japan Stroke Society

Kazunori Toyoda et al. Neurol Med Chir (Tokyo). .
No abstract available

Keywords: Guideline; Japan; acute ischemic stroke; alteplase; thrombolysis.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Guidelines for Practice of IV Thrombolysis for Stroke that Developed in Patients Treated with Dabigatran. Excerpt from Special Working Group in the Committee on Medical Improvement and Social Insurance, Japan Stroke Society.
Fig. 2
Fig. 2
Flow from hospital arrival to initiation of IV thrombolysis. The above medical examination, blood testing, and explanation should be performed simultaneously, if possible, and a minimum goal for each institution is <60 min of hospital arrival and initiation of IV thrombolysis (the sooner, the better).
Fig. 3
Fig. 3
Flow of events in case of lack of a patient’s ability to understand explanation for judgement when the patient’s legal representative is absent.
See this image and copyright information in PMC

References

    1. Yamaguchi T, Mori E, Minematsu K, et al. : Alteplase at 0.6 mg/kg for acute ischemic stroke within 3 hours of onset: Japan Alteplase Clinical Trial (J-ACT). Stroke 37: 1810–1815, 2006 - PubMed
    1. Guideline Committee of the Japan Stroke Society for the intravenous rt-PA (alteplase) in acute ischemic stroke. Jpn J Stroke 27: 327–354, 2005. (Japanese)
    1. Minematsu K, Toyoda K, Hirano T, et al. : Guidelines for the intravenous application of recombinant tissue-type plasminogen activator (alteplase), the second edition, October 2012: a guideline from the Japan Stroke Society. J Stroke Cerebrovasc Dis 22: 571–600, 2013 - PubMed
    1. Guideline Committee of the Japan Stroke Society for the intravenous rt-PA (alteplase) in acute ischemic stroke. Guidelines for intravenous application of rt-PA (alteplase), October 2012, partly revised in September 2016. Jpn J Stroke 39: 43–86, 2017. (Japanese)
    1. Guideline Committee of the Japan Stroke Society, Japan Neurosurgical Society, and Japanese Society for Endovascular Therapy. Guidelines for Mechanical Thrombectomy, the third edition, March 2018. Jpn J Stroke 40: 285–309, 2018. (Japanese)

Publication types

MeSH terms