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. 2020 Sep 12;71(6):1367-1376.
doi: 10.1093/cid/ciz1008.

Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium

J Peter Donnelly  1 , Sharon C Chen  2 , Carol A Kauffman  3 , William J Steinbach  4 , John W Baddley  5 , Paul E Verweij  6 , Cornelius J Clancy  7 , John R Wingard  8 , Shawn R Lockhart  9 , Andreas H Groll  10 , Tania C Sorrell  11 , Matteo Bassetti  12 , Hamdi Akan  13 , Barbara D Alexander  14 , David Andes  15 , Elie Azoulay  16 , Ralf Bialek  17 , Robert W Bradsher  18 , Stephane Bretagne  19 , Thierry Calandra  20 , Angela M Caliendo  21 , Elio Castagnola  22 , Mario Cruciani  23 , Manuel Cuenca-Estrella  24 , Catherine F Decker  25 , Sujal R Desai  26 , Brian Fisher  27 , Thomas Harrison  28 , Claus Peter Heussel  29 , Henrik E Jensen  30 , Christopher C Kibbler  31 , Dimitrios P Kontoyiannis  32 , Bart-Jan Kullberg  33 , Katrien Lagrou  34 , Frédéric Lamoth  35 , Thomas Lehrnbecher  36 , Jurgen Loeffler  37 , Olivier Lortholary  38 , Johan Maertens  39   40 , Oscar Marchetti  20 , Kieren A Marr  41 , Henry Masur  42 , Jacques F Meis  43 , C Orla Morrisey  44 , Marcio Nucci  45 , Luis Ostrosky-Zeichner  46 , Livio Pagano  47 , Thomas F Patterson  48 , John R Perfect  14 , Zdenek Racil  49 , Emmanuel Roilides  50 , Marcus Ruhnke  51 , Cornelia Schaefer Prokop  52 , Shmuel Shoham  41 , Monica A Slavin  53 , David A Stevens  54   55 , George R Thompson  56 , Jose A Vazquez  57 , Claudio Viscoli  58 , Thomas J Walsh  59 , Adilia Warris  60 , L Joseph Wheat  61 , P Lewis White  62 , Theoklis E Zaoutis  63 , Peter G Pappas  5
Affiliations

Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium

J Peter Donnelly et al. Clin Infect Dis. .

Abstract

Background: Invasive fungal diseases (IFDs) remain important causes of morbidity and mortality. The consensus definitions of the Infectious Diseases Group of the European Organization for Research and Treatment of Cancer and the Mycoses Study Group have been of immense value to researchers who conduct clinical trials of antifungals, assess diagnostic tests, and undertake epidemiologic studies. However, their utility has not extended beyond patients with cancer or recipients of stem cell or solid organ transplants. With newer diagnostic techniques available, it was clear that an update of these definitions was essential.

Methods: To achieve this, 10 working groups looked closely at imaging, laboratory diagnosis, and special populations at risk of IFD. A final version of the manuscript was agreed upon after the groups' findings were presented at a scientific symposium and after a 3-month period for public comment. There were several rounds of discussion before a final version of the manuscript was approved.

Results: There is no change in the classifications of "proven," "probable," and "possible" IFD, although the definition of "probable" has been expanded and the scope of the category "possible" has been diminished. The category of proven IFD can apply to any patient, regardless of whether the patient is immunocompromised. The probable and possible categories are proposed for immunocompromised patients only, except for endemic mycoses.

Conclusions: These updated definitions of IFDs should prove applicable in clinical, diagnostic, and epidemiologic research of a broader range of patients at high-risk.

Keywords: consensus; definitions; diagnosis; invasive fungal diseases; research.

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References

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