Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2020 May;35(5):423-432.
doi: 10.14670/HH-18-189. Epub 2019 Dec 5.

Role of androgen receptor expression in non-muscle-invasive bladder cancer: a systematic review and meta-analysis

Francesca Sanguedolce  1   2 , Luigi Cormio  3 , Giuseppe Carrieri  3 , Beppe Calò  3 , Davide Russo  4 , Andrea Menin  5 , Antonio Luigi Pastore  2   6 , Francesco Greco  2   7 , Giorgio Bozzini  2   8 , Antonio Galfano  2   9 , Giovannalberto Pini  2   10 , Angelo Porreca  2   11 , Filippo Mugavero  2   12 , Mario Falsaperla  2   12 , Carlo Ceruti  2   13 , Luca Cindolo  2   14 , Alessandro Antonelli  2   15 , Andrea Minervini  2   16
Affiliations
Meta-Analysis

Role of androgen receptor expression in non-muscle-invasive bladder cancer: a systematic review and meta-analysis

Francesca Sanguedolce et al. Histol Histopathol. 2020 May.

Abstract

In order to evaluate the potential prognostic/predictive role of androgen receptor (AR) expression in non-muscle-invasive bladder cancer (NMIBC), and whether it may represent a therapeutic target, we conducted a systematic search of the literature using 'androgen receptor or AR', 'testosterone', 'bladder cancer' and 'non-muscle invasive bladder cancer or NMIBC' as keywords. Eleven studies met the inclusion/exclusion criteria. No significant association was found between AR status and patients' gender (p=0.232), tumor size (p=0.975), tumor stage (p=0.237), tumor grade (p=0.444), tumor multicentricity (p=0.397), concomitant CIS (p=0.316) and progression of disease (p=0.397). On the other hand, relative lack of AR expression was significantly correlated to recurrent disease (p=0.001). Evidence for a direct correlation between AR expression and recurrence-free survival of patients with NMIBC indicate ARs as potential markers of BC behavior; moreover, the finding of a role of androgen blockade therapy in improving survival highlights the potential clinical application of this pathway, which deserves to be further explored.

PubMed Disclaimer

References

    1. Babjuk M., Böhle A., Burger M., Capoun O., Cohen D., Compérat E.M., Hernandez V., Kaasinen E., Palou J., Roupret M., van Rhijn B.W., Shariat S.F., Soukup V., Sylvester R.J. and Zigeuner R. (2017). EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder: Update 2016. Eur. Urol. 7, 447-461. - PubMed
    1. Boorjian S., Ugras S., Mongan N.P., Gudas L.J., You X., Tickoo S.K. and Scherr D.S. (2004). Androgen receptor expression is inversely correlated with pathologic tumor stage in bladder cancer. Urology 64, 383-388. - PubMed
    1. Boorjian S.A., Heemers H.V., Frank I., Farmer S.A., Schmidt L.J., Sebo T.J. and Tindall D.J. (2009). Expression and significance of androgen receptor coactivators in urothelial carcinoma of the bladder. Endocr. Relat. Cancer 16, 123-137. - PMC - PubMed
    1. Bray F., Jemal A., Grey N., Ferlay J. and Forman D (2011). Global cancer transitions according to the Human Development Index (2008-2030): a population-based study. Lancet Oncol. 13, 790-801. - PubMed
    1. Burge F. and Kockelbergh R. (2016). Closing the gender gap: Can we improve bladder cancer survival in women? - A systematic review of diagnosis, treatment and outcomes. Urol. Int. 97, 373-379. - PubMed

Grants and funding