Vitamin D metabolism in dogs and cats and its relation to diseases not associated with bone metabolism

doi:10.1111/jpn.13259

Review

. 2020 Jan;104(1):322-342.

doi: 10.1111/jpn.13259. Epub 2019 Dec 5.

Vitamin D metabolism in dogs and cats and its relation to diseases not associated with bone metabolism

Rafael V A Zafalon¹, Larissa W Risolia¹, Vivian Pedrinelli¹, Thiago H A Vendramini¹, Roberta B A Rodrigues¹, Andressa R Amaral¹, Marcia M Kogika¹, Marcio A Brunetto¹

Affiliations

PMID: 31803981
DOI: 10.1111/jpn.13259

Review

Vitamin D metabolism in dogs and cats and its relation to diseases not associated with bone metabolism

Rafael V A Zafalon et al. J Anim Physiol Anim Nutr (Berl). 2020 Jan.

. 2020 Jan;104(1):322-342.

doi: 10.1111/jpn.13259. Epub 2019 Dec 5.

Authors

Rafael V A Zafalon¹, Larissa W Risolia¹, Vivian Pedrinelli¹, Thiago H A Vendramini¹, Roberta B A Rodrigues¹, Andressa R Amaral¹, Marcia M Kogika¹, Marcio A Brunetto¹

Affiliation

¹ School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.

PMID: 31803981
DOI: 10.1111/jpn.13259

Abstract

Due to the presence of receptors in the cells of numerous body tissues, vitamin D is associated with several physiological functions that go beyond calcium and phosphorus homoeostasis and control of bone metabolism in the body. In humans, several studies have associated lower vitamin D concentrations with numerous diseases, such as cancer, heart disease, autoimmune diseases and infectious diseases, and also with an increase in the total mortality rate of the population. Recently, this nutrient started to gain importance in veterinary medicine, and several articles have shown a correlation between low vitamin D status and diseases unrelated to bone metabolism. The present review aims to highlight the recent publications that investigated this relationship, bringing the evidence that exists so far in dogs and cats.

Keywords: 1,25(OH)2D; 25(OH)D; calcidiol; calcitriol; cholecalciferol; hypovitaminosis D.

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Increased dietary vitamin D was associated with increased circulating vitamin D with no observable adverse effects in adult dogs.
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References

REFERENCES

1. Agarwal, R., Acharya, M., Tian, J., Hippensteel, R. L., Melnick, J. Z., Qiu, P., … Batlle, D. (2005). Antiproteinuric effect of oral paricalcitol in chronic kidney disease. Kidney International, 68(6), 2823-2828. https://doi.org/10.1111/j.1523-1755.2005.00755.x
1. Aguilera, O., Peña, C., García, J. M., Larriba, M. J., Ordóñez-Morán, P., Navarro, D., … Esteller, M. (2007). The Wnt antagonist DICKKOPF-1 gene is induced by 1α, 25-dihydroxyvitamin D 3 associated to the differentiation of human colon cancer cells. Carcinogenesis, 28(9), 1877-1884. https://doi.org/10.1093/carcin/bgm094
1. Allenspach, K., Rizzo, J., Jergens, A. E., & Chang, Y. M. (2017). Hypovitaminosis D is associated with negative outcome in dogs with protein losing enteropathy: A retrospective study of 43 cases. BMC Veterinary Research, 13(1), 96. https://doi.org/10.1186/s12917-017-1022-7
1. Anand, S. P., & Selvaraj, P. (2009). Effect of 1, 25 dihydroxyvitamin D3 on matrix metalloproteinases MMP-7, MMP-9 and the inhibitor TIMP-1 in pulmonary tuberculosis. Clinical Immunology, 133(1), 126-131. https://doi.org/10.1016/j.clim.2009.06.009
1. Anwar, E., Hamdy, G., Taher, E., Fawzy, E., Abdulattif, S., & Attia, M. H. (2017). Burden and outcome of vitamin D deficiency among critically ill patients: A prospective study. Nutrition in Clinical Practice, 32(3), 378-384. https://doi.org/10.1177/0884533616671741

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[1] Agarwal, R., Acharya, M., Tian, J., Hippensteel, R. L., Melnick, J. Z., Qiu, P., … Batlle, D. (2005). Antiproteinuric effect of oral paricalcitol in chronic kidney disease. Kidney International, 68(6), 2823-2828. https://doi.org/10.1111/j.1523-1755.2005.00755.x

[2] Agarwal, R., Acharya, M., Tian, J., Hippensteel, R. L., Melnick, J. Z., Qiu, P., … Batlle, D. (2005). Antiproteinuric effect of oral paricalcitol in chronic kidney disease. Kidney International, 68(6), 2823-2828. https://doi.org/10.1111/j.1523-1755.2005.00755.x

[3] Aguilera, O., Peña, C., García, J. M., Larriba, M. J., Ordóñez-Morán, P., Navarro, D., … Esteller, M. (2007). The Wnt antagonist DICKKOPF-1 gene is induced by 1α, 25-dihydroxyvitamin D 3 associated to the differentiation of human colon cancer cells. Carcinogenesis, 28(9), 1877-1884. https://doi.org/10.1093/carcin/bgm094

[4] Aguilera, O., Peña, C., García, J. M., Larriba, M. J., Ordóñez-Morán, P., Navarro, D., … Esteller, M. (2007). The Wnt antagonist DICKKOPF-1 gene is induced by 1α, 25-dihydroxyvitamin D 3 associated to the differentiation of human colon cancer cells. Carcinogenesis, 28(9), 1877-1884. https://doi.org/10.1093/carcin/bgm094

[5] Allenspach, K., Rizzo, J., Jergens, A. E., & Chang, Y. M. (2017). Hypovitaminosis D is associated with negative outcome in dogs with protein losing enteropathy: A retrospective study of 43 cases. BMC Veterinary Research, 13(1), 96. https://doi.org/10.1186/s12917-017-1022-7

[6] Allenspach, K., Rizzo, J., Jergens, A. E., & Chang, Y. M. (2017). Hypovitaminosis D is associated with negative outcome in dogs with protein losing enteropathy: A retrospective study of 43 cases. BMC Veterinary Research, 13(1), 96. https://doi.org/10.1186/s12917-017-1022-7

[7] Anand, S. P., & Selvaraj, P. (2009). Effect of 1, 25 dihydroxyvitamin D3 on matrix metalloproteinases MMP-7, MMP-9 and the inhibitor TIMP-1 in pulmonary tuberculosis. Clinical Immunology, 133(1), 126-131. https://doi.org/10.1016/j.clim.2009.06.009

[8] Anand, S. P., & Selvaraj, P. (2009). Effect of 1, 25 dihydroxyvitamin D3 on matrix metalloproteinases MMP-7, MMP-9 and the inhibitor TIMP-1 in pulmonary tuberculosis. Clinical Immunology, 133(1), 126-131. https://doi.org/10.1016/j.clim.2009.06.009

[9] Anwar, E., Hamdy, G., Taher, E., Fawzy, E., Abdulattif, S., & Attia, M. H. (2017). Burden and outcome of vitamin D deficiency among critically ill patients: A prospective study. Nutrition in Clinical Practice, 32(3), 378-384. https://doi.org/10.1177/0884533616671741

[10] Anwar, E., Hamdy, G., Taher, E., Fawzy, E., Abdulattif, S., & Attia, M. H. (2017). Burden and outcome of vitamin D deficiency among critically ill patients: A prospective study. Nutrition in Clinical Practice, 32(3), 378-384. https://doi.org/10.1177/0884533616671741

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Vitamin D metabolism in dogs and cats and its relation to diseases not associated with bone metabolism

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Vitamin D metabolism in dogs and cats and its relation to diseases not associated with bone metabolism

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