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Published Erratum
. 2020 Jan;14(1):230-231.
doi: 10.1002/1878-0261.12604. Epub 2019 Dec 5.

Erratum to: Disruption of the RICTOR/mTORC2 complex enhances the response of head and neck squamous cell carcinoma cells to PI3K inhibition

Kara M Ruicci, Paul Plantinga, Nicole Pinto, Mohammed I Khan, William Stecho, Sandeep S Dhaliwal, John Yoo, Kevin Fung, Danielle MacNeil, Joe S Mymryk, John W Barrett, Christopher J Howlett, Anthony C Nichols
Published Erratum

Erratum to: Disruption of the RICTOR/mTORC2 complex enhances the response of head and neck squamous cell carcinoma cells to PI3K inhibition

Kara M Ruicci et al. Mol Oncol. 2020 Jan.
No abstract available

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Figures

Figure 4
Figure 4
Deletion of RICTOR exon 5 disrupts the interaction between RICTOR and mTOR. (A) Schematic illustrating design of single‐guide RNA and primers for CRISPR/Cas9‐mediated deletion of exon 5 of RICTOR. (B) Predicted genotypes and base pair sizes for genomic PCR amplicons of RICTOR following CRISPR/Cas9 targeting of RICTOR. (C) Agarose gel images showing RICTOR amplicons in cell populations (FaDu, Cal27 cells) transfected with guides targeting RICTOR or an empty vector (PX458‐CMV). (D) Immunoblot of RICTOR expression in parental and mutant cell lines (E5‐XX lines). (E) Immunoblot showing co‐IP of RICTOR and mTOR in FaDu and Cal27 cells, but no detectable interaction in any of the putative RICTOR knockout cell lines.
See this image and copyright information in PMC

Erratum for

References

    1. Ruicci KM, Plantinga P, Pinto N, Khan MI, Stecho W, Dhaliwal SS, Yoo J, Fung K, MacNeil D, Mymryk JS et al (2019) Disruption of the RICTOR/mTORC2 complex enhances the response of head and neck squamous cell carcinoma cells to PI3K inhibition. Mol Oncol 13, 2160–2177. 10.1002/1878-0261.12558 - DOI - PMC - PubMed

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