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Review
. 2020 Aug;54(2):154-167.
doi: 10.1097/SHK.0000000000001484.

Burn-Induced Coagulopathies: a Comprehensive Review

Robert L Ball  1   2 , John W Keyloun  1   2   3 , Kathleen Brummel-Ziedins  4 , Thomas Orfeo  4 , Tina L Palmieri  5 , Laura S Johnson  1   2   3 , Lauren T Moffatt  1   2 , Anthony E Pusateri  6 , Jeffrey W Shupp  1   2   3
Affiliations
Review

Burn-Induced Coagulopathies: a Comprehensive Review

Robert L Ball et al. Shock. 2020 Aug.

Abstract

Burn-induced coagulopathy is not well understood, and consensus on diagnosis, prevention, and treatments are lacking. In this review, literature on burn-induced (and associated) coagulopathy is presented along with the current understanding of the effects of burn injury on the interactions among coagulation, fibrinolysis, and inflammation in the acute resuscitative phase and reconstructive phase of care. The role of conventional tests of coagulopathy and functional assays like thromboelastography or thromboelastometry will also be discussed. Finally, reported methods for the prevention and treatment of complications related to burn-induced coagulopathy will be reviewed.

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Conflict of interest statement

The authors report no conflicts of interest.

Figures

Fig. 1
Fig. 1
A simplified schematic illustrating a patient's hospital course after burn injury.
Fig. 2
Fig. 2
Pathways to thrombin generation: Extrinsic pathway: Extravascular TF, exposed as a result of vascular injury, forms a complex with circulating FVIIa forming the extrinsic tenase (“1”) which activates FIX and FX.
Fig. 3
Fig. 3
Pathways linking fibrin formation and fibrinolysis.
See this image and copyright information in PMC

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