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. 1988 Jul-Sep;6(3):221-5.

HLA antigens and clinical manifestations in Crohn's disease

V Modena  1 , A Amoroso, C Frattasio, A Pera, P Costantini, I Maiocco, V Ponti, C C Di Vittorio, G Verme, E S Curtoni
Affiliations
  • PMID: 3180544

HLA antigens and clinical manifestations in Crohn's disease

V Modena et al. Clin Exp Rheumatol. 1988 Jul-Sep.

Abstract

A clinical, radiological and immunogenetical study was carried out on 51 Crohn's patients. Rheumatological disorders were found in 16 of them, with higher frequency in those with colon involvement only. A statistically significant increase in the frequencies of HLA-A9 and HLA-Cw3 was noted: Cw3 showed a particularly high frequency in males, and A9 in younger patients. The frequency of HLA-B27 was significantly increased in the patients with colon involvement. In the group of 16 patients with rheumatic diseases HLA antigen frequencies were not significantly different from the control population.

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