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. 2019 Dec 5;15(1):440.
doi: 10.1186/s12917-019-2201-5.

Changes in specific serum biomarkers during the induction of prostatic hyperplasia in dogs

Kamran Golchin-Rad  1 , Asghar Mogheiseh  2 , Saeed Nazifi  1 , Mohammad Saeed Ahrari Khafi  1 , Nooshin Derakhshandeh  1 , Mohammad Abbaszadeh-Hasiri  1
Affiliations

Changes in specific serum biomarkers during the induction of prostatic hyperplasia in dogs

Kamran Golchin-Rad et al. BMC Vet Res. .

Abstract

Background: Prostatic hyperplasia (PH) is one of the most important disorders in intact dogs. In this study, we aimed to induce PH experimentally using the combination of testosterone and estrogen and evaluate important factors associated with this disease.

Results: The results showed that in the induction group, prostate volume and prostate specific antigen (PSA) concentration increased significantly on day 21 onwards compared to those of the control group. Canine prostatic specific esterase (CPSE) and dihydrotestosterone (DHT) concentrations increased significantly on day 42 onwards while the testosterone levels increased on day 63. In addition, prostatic acid phosphatase (PAP) concentration did not change significantly in the control and induction groups. Biochemistry profiles and hematologic factors were measured for monitoring the function of liver and kidney, and there were no adverse effects following the induction of PH.

Conclusions: It seems that testosterone and estrogen administration led to prostatic hyperplasia during 2 months. Investigating the size of the prostate, accompanied by prostate markers including CPSE, PSA, DHT, and testosterone, is helpful for the PH diagnosis. However, further studies should be carried out on PAP.

Keywords: Canine prostate specific esterase; Dog; Estrogen; Prostate specific antigen; Prostatic hyperplasia; Testosterone.

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Conflict of interest statement

We would like to confirm that there are no known conflicts of interest associated with this publication.

Figures

Fig. 1
Fig. 1
Changes and comparison of the prostatic volume during the induction of PH with testosterone and estrogen in the control and PH-induced groups of intact dogs (n = 20). Significant differences between the groups are indicated with different letters above the columns
Fig. 2
Fig. 2
Changes and comparison of blood serum CPSE concentration during the induction of PH with testosterone and estrogen in the control and PH-induced groups of intact dogs (n = 20). Significant differences between the groups are indicated with different letters above the columns
Fig. 3
Fig. 3
Changes and comparison of serum PSA concentration during the induction of PH with testosterone and estrogen in the control and PH-induced groups of intact dogs (n = 20). Significant differences between the groups are indicated with different letters above the columns
Fig. 4
Fig. 4
Changes and comparison of serum PAP concentration during the induction of PH with testosterone and estrogen in the control and PH-induced groups of intact dogs (n = 20). Significant differences between the groups are indicated with different letters above the columns
Fig. 5
Fig. 5
Changes and comparison of serum testosterone concentration during the induction of PH with testosterone and estrogen in the control and PH-induced groups of intact dogs (n = 20). Significant differences between the groups are indicated with different letters above the columns
Fig. 6
Fig. 6
Changes and comparison of dihydrotestosterone concentration during the induction of PH with testosterone and estrogen in the control and PH-induced groups of intact dogs (n = 20). Significant differences between the groups are indicated with different letters above the columns
Fig. 7
Fig. 7
The correlation and regression were analyzed between the prostate volume and CPSE and PSA concentrations during the induction of PH and there was a significant positive correlation between the PSA concentration and prostate volume (Y = 174.7*X + 12.83; r2 = 0.18; P < 0.005) and between the CPSE level and prostate volume during the induction of PH in dogs (Y = 0.09936*X + 6.424; r2 = 0.18; P < 0.006). Also, there was a significant positive correlation between the PSA and CPSE levels during the induction of PH in dogs (Y = 1187X + 78.53; r2 = 0.68; P < 0.0001)
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References

    1. Atalan G, Holt P, Barr F, Brown P. Ultrasonographic estimation of prostatic size in canine cadavers. Res Vet Sci. 1999;67(1):7–15. - PubMed
    1. Berry SJ, Strandberg JD, Coffey DS, Saunders WJ. Development of canine benign prostatic hyperplasia with age. Prostate. 1986;9(4):363–373. - PubMed
    1. Barsanti J, Prasse K, Crowell W, Shotts E, Finco D. Evaluation of various techniques for diagnosis of chronic bacterial prostatitis in the dog [Escherichia coli] J Am Vet Med A. 1983;183(2):219–224. - PubMed
    1. Krawiec D, Heflin D. Study of prostatic disease in dogs: 177 cases (1981-1986) J Am Vet Med A. 1992;200(8):1809–1819. - PubMed
    1. Paclikova K, Kohout P, Vlasin M. Diagnostic possibilities in the management of canine prostatic disorders. Vet Med Praha. 2006;51(1):1.