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. 2020 Jan;41(1):1-3.
doi: 10.1016/j.it.2019.11.009. Epub 2019 Dec 3.

Genetic Variation Shapes Murine Gut Microbiota via Immunity

Emily R Davenport  1
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Genetic Variation Shapes Murine Gut Microbiota via Immunity

Emily R Davenport. Trends Immunol. 2020 Jan.

Abstract

Host genetics influence gut microbiome composition. However, determining the specific physiological mechanisms and microbes affected has been difficult due to 'cage' and 'legacy' effects in model systems. Recently, Khan et al. cleverly colonized ex-germ-free mice to demonstrate that immune genes regulate select bacterial lineages in the mouse gut.

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