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Comment
. 2020 Jan;10(1):7-8.
doi: 10.1158/2159-8290.CD-NB2019-136. Epub 2019 Dec 5.

Siglec-15: An Attractive Immunotherapy Target

No authors listed
Comment

Siglec-15: An Attractive Immunotherapy Target

No authors listed. Cancer Discov. 2020 Jan.

Abstract

Siglec-15, which selectively drives immunosuppression in the tumor microenvironment, has emerged as a viable therapeutic target. In a phase I trial of NC318, a Siglec-15 antibody, encouraging efficacy was seen, including a complete response in non-small cell lung cancer refractory to PD-1 blockade.

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