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Review
. 2019 Nov 1:11:237-252.
doi: 10.2147/OARRR.S174408. eCollection 2019.

Depression And Anxiety In Patients With Juvenile Idiopathic Arthritis: Current Insights And Impact On Quality Of Life, A Systematic Review

Danielle C Fair  1 , Martha Rodriguez  2 , Andrea M Knight  3 , Tamar B Rubinstein  4
Affiliations
Review

Depression And Anxiety In Patients With Juvenile Idiopathic Arthritis: Current Insights And Impact On Quality Of Life, A Systematic Review

Danielle C Fair et al. Open Access Rheumatol. .

Abstract

Depression and anxiety are prevalent in children with rheumatologic diseases, including juvenile idiopathic arthritis (JIA). However, prevalence rates and the relationship with disease outcomes, including quality of life are conflicting in the early literature. To review the current literature, determine gaps in our knowledge, and identify areas in need of further investigation, we conducted a systematic review of studies examining depression and anxiety symptoms among children with JIA and the impact these symptoms may have on disease outcomes and quality of life. Six electronic databases were searched up until January 2019. Of 799 potential articles, 60 articles were included with the main focus on 28 articles from 2009 to 2019, to concentrate on the most current evidence. We found that JIA patients experience symptoms of depression and anxiety similar to other childhood chronic diseases and at higher rates than in healthy children. Patients who experience these symptoms have worse quality of life, with some evidence pointing to depression and anxiety symptoms having a greater impact on quality of life than other disease features, such as active joint count. Family members of JIA patients experience high rates of anxiety and depression symptoms which may impact their child's mental health and pain symptoms related to JIA. Conflicting reports of associations between depression/anxiety symptoms and disease features/disease outcomes and a paucity of longitudinal studies investigating the impact of treatment on mental health symptoms indicate areas in need of further research to effectively identify patients at greatest risk of depression and anxiety and to better understand how to treat and prevent these symptoms in youth with JIA. Family mental health should also be considered in investigations concerning mental health and disease outcomes of children with JIA.

Keywords: arthritis; autoimmune disease; mental health; mood disorder; pediatric rheumatology.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Flowchart of selection process for study inclusion in the systematic review.
See this image and copyright information in PMC

References

    1. Petty RE, Laxer RM, Wedderburn LR. Juvenile Idiopathic Arthritis In: Petty RE, Laxer RM, Lindsley CB, Wedderburn LR, editors. Textbook of Pediatric Rheumatology. 7th ed. Philadelphia: Elsevier; 2016:188–204.
    1. Thierry S, Fautrel B, Lemelle I, Guillemin F. Prevalence and incidence of juvenile idiopathic arthritis: a systematic review. Joint Bone Spine. 2014;81(2):112–117. doi:10.1016/j.jbspin.2013.09.003 - DOI - PubMed
    1. Lu W. Adolescent depression: national trends, risk factors, and healthcare disparities. Am J Health Behav. 2019;43(1):181–194. doi:10.5993/AJHB.43.1.15 - DOI - PubMed
    1. Ferro MA, Boyle MH. The impact of chronic physical illness, maternal depressive symptoms, family functioning, and self-esteem on symptoms of anxiety and depression in children. J Abnormal Child Psychol. 2015;43(1):177–187. doi:10.1007/s10802-014-9893-6 - DOI - PubMed
    1. Pinquart M, Shen Y. Depressive symptoms in children and adolescents with chronic physical illness: an updated meta-analysis. J Pediatr Psychol. 2011;36(4):375–384. doi:10.1093/jpepsy/jsq104 - DOI - PubMed

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