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. 2020 Apr;146(4):1101-1102.
doi: 10.1007/s00432-019-03105-9. Epub 2019 Dec 5.

Hyperthermia, positive feedback loop with IL-6 and risk of NSCLC progression: a tangle to unravel?

Raffaella Mormile  1
Affiliations

Hyperthermia, positive feedback loop with IL-6 and risk of NSCLC progression: a tangle to unravel?

Raffaella Mormile. J Cancer Res Clin Oncol. 2020 Apr.

Abstract

Fever may represent a risk factor for NSCLC by increasing IL-6 expression. In this light, an accurate and rapid control of fever among lung cancer patients should be carefully added to the treatment plan. On this regard, concerns increase when doubts arise regarding the applicability of hyperthermia on NSCLC given the potential interaction of IL-6 with NSCLC. Thus, I suggest that randomized, controlled double-arm clinical studies are warranted for an evidence-based evaluation of feasibility of the hyperthermia application in the management of NSCLC.

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Conflict of interest statement

The author declares no potential conflicts of interest.

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